80473-92-3
中文名稱
(6A,11B,16A,17A)-6,9-二氟-11,17-二羥基-16-甲基-3-氧代雄甾-1,4-二烯-17-硫代羧酸
英文名稱
Androsta-1,4-diene-17-carbothioic acid, 6,9-difluoro-11,17-dihydroxy-16-methyl-3-oxo-, (6a,11b,16a,17a)-
CAS
80473-92-3
分子式
C21H26F2O4S
分子量
412.49
MOL 文件
80473-92-3.mol
更新日期
2026/07/16 12:18:39
80473-92-3 結(jié)構(gòu)式
基本信息
中文別名
氟替卡松雜質(zhì)32氟替卡松中間體 FT5
6Α,9Α-二氟-11Β,17Α-二羥基-16Α-甲基-3-氧代雄甾-1,4-二烯-17Α-硫代羧酸
(6A,11B,16A,17A)-6,9-二氟-11,17-二羥基-16-甲基-3-氧代雄甾-1,4-二烯-17-硫代羧酸
英文別名
Axon 1171(6α,11,16α,17α)-
Fluticasone Thioacid
Fluticasone Impurity 41
Fluticasone intermediate F2
11,17-dihydroxy-16-methyl-3-oxo-,(6α,11β,16α,17α)-
Androsta-1,4-diene-17-carbothioic acid, 6,9-difluoro-
6a,9a-Difluoro-11b,17a-dihydroxy-16a-methyl-3-oxoandrosta-1,4-diene-17b-carbothioic acid
6α,9α-Difluoro-11β,17α-dihydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17a-carbothioic acid
(6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carbothioic acid
所屬類別
天然產(chǎn)物：甾體化合物物理化學(xué)性質(zhì)
熔點(diǎn)230-231 °C
沸點(diǎn)550.0±50.0 °C(Predicted)
密度1.36±0.1 g/cm3(Predicted)
儲(chǔ)存條件Sealed in dry,2-8°C
溶解度DMSO (Slightly), Methanol (Sparingly)
酸度系數(shù)(pKa)3.74±0.70(Predicted)
形態(tài)Solid:particulate/powder
InChIKeyGLAJUXBOZSWZMM-TXKOFOEMNA-N
SMILESC1=C[C@]2(C([C@@H](F)C[C@]3([C@]4([H])C[C@@H](C)[C@](O)(C(=S)O)[C@@]4(C)C[C@H](O)[C@]23F)[H])=CC1=O)C |&1:2,4,7,8,11,13,18,21,23,r|
LogP1.298 at 22℃ and pH4.81-4.91
表面張力55.7mN/m at 9mg/L and 20℃
