805239-56-9
中文名稱
805239-56-9
英文名稱
4-[2-PHENYL-5,7-BIS(TRIFLUOROMETHYL)PYRAZOLO[1,5-A]PYRIMIDIN-3-YL]PHENOL
CAS
805239-56-9
分子式
C20H11F6N3O
分子量
423.31
MOL 文件
805239-56-9.mol
更新日期
2026/07/08 15:10:47
805239-56-9 結(jié)構(gòu)式
基本信息
中文別名
化合物PHTPP4-[2-PHENYL-5,7-BIS(TRIFLUOROMETHYL)PYRA...
2-苯基-3-(4-羥基苯基)-5,7-雙(三氟甲基)-吡唑并[1,5-A] 嘧啶, 4-[2-苯基-5,7-雙(三氟甲基)吡唑并[1,5-A]-嘧啶-3-基] 苯酚
英文別名
PHTPP4-[2-phenyl-5
5-a]pyrimidin-3-yl]phenol
7-bis(trifluoromethyl)pyrazolo[1
4-[2-PHENYL-5，7-BIS(TRIFLUOROMETHYL)PYRA...
4-[2-PHENYL-5,7-BIS(TRIFLUOROMETHYL)PYRAZOLO[1,5-A]PYRIMIDIN-3-YL]PHENOL
Phenol, 4-[2-phenyl-5,7-bis(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-3-yl]-
所屬類別
生物：拮抗劑物理化學(xué)性質(zhì)
儲存條件2-8°C
溶解度DMSO : 25 mg/mL (59.06 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)
形態(tài)粉末
顏色黃色到橙色
InChI1S/C20H11F6N3O/c21-19(22,23)14-10-15(20(24,25)26)29-18(27-14)16(11-6-8-13(30)9-7-11)17(28-29)12-4-2-1-3-5-12/h1-10,30H
InChIKeyAEZPAUSGTAHLOQ-UHFFFAOYSA-N
SMILESOC(C=C1)=CC=C1C(C(C2=CC=CC=C2)=N3)=C4N3C(C(F)(F)F)=CC(C(F)(F)F)=N4
安全數(shù)據(jù)
警示詞危險
危險性描述H301
防范說明P301+P310+P330
危險品運輸編號UN 2811 6.1 / PGIII
WGK GermanyWGK 3
存儲類別6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects
toxic compounds or compounds which causing chronic effects
危險性類別Acute Tox. 3 Oral
PHTPP價格(試劑級)
| 報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
| 2026/06/05 | HY-103456R | PHTPP PHTPP (Standard) | 805239-56-9 | 5 mg | 1320元 |
| 2026/06/05 | HY-103456R | PHTPP PHTPP (Standard) | 805239-56-9 | 10 mg | 1980元 |
| 2026/06/05 | HY-103456R | PHTPP PHTPP (Standard) | 805239-56-9 | 25 mg | 3564元 |
常見問題列表
生物活性
PHTPP 是一種選擇性雌激素受體 β (ERβ) 拮抗劑，其選擇性是 ERα 的 36 倍。靶點
ERβ
體外研究
PHTPP is a selective ERβ antagonist. PHTPP reduces FSH-mediated cAMP production by 80% (p<0.01) while it has no effect on basal cAMP. PHTPP (10 -6 M) inhibits E2-stimulated ERβ activity, but does not suppress E2-stimulated ERα activity. A high dose of PHTPP (10 -6 M) slightly increases class 1 Igf1 mRNA expression, and facilitates the DPN-induced increase in class 1 Igf1 mRNA expression.