823218-99-1
823218-99-1 結(jié)構(gòu)式
基本信息
3-均三甲苯基-3A,4,5,6,7,7A-六氫-4,7-亞甲基苯并[D]異惡唑
SN2
SN-2
3a,4,5,6,7,7a-Hexahydro-3-(2,4,6-trimethylphenyl)-4,7-methano-1,2-benzisoxazole
4,7-Methano-1,2-benzisoxazole, 3a,4,5,6,7,7a-hexahydro-3-(2,4,6-trimethylphenyl)-
物理化學(xué)性質(zhì)
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2026/06/05 | HY-16696 | CS-1190 SN 2 | 823218-99-1 | 1 mg | 181元 |
| 2026/06/05 | HY-16696 | CS-1190 SN 2 | 823218-99-1 | 5 mg | 445元 |
| 2026/06/05 | HY-16696 | CS-1190 SN 2 | 823218-99-1 | 10 mM * 1 mL in DMSO | 489元 |
常見問題列表
EC50: 1.8±0.13 μM (TRPML3), >29.9 μM (TRPML1)
The conductance of TRPML3 channels is estimate, when activated with 10 μM SN-2 is approximately 10 pS at ?80 mV. TRPML3-expressing HEK293 cells are perfused with a series starting with compound alone (in SBS), with compound in ELS, and finally with ELS alone. Two representative compounds, SF-24 and SN-2, are tested. SF-24 is one of the least effective compounds, and SN-2 is one of the most active ones. SN-2 has a similar synergistic effect, also reaching up-to 10-fold enhancement of the combined response when compared with the individual responses, reaching average current densities of up to 3 nA/pF at ?80 mV. Dominant negative TRPML3(D458K) is highly effective in eliminating SN-2-induced activity in epidermal melanocytes, suggesting that SN-2 activates a channel that is not responsive in presence of TRPML3(D458K). Such a dominant negative action might be attributed to potential heteromerization of TRPML3(D458K) with an SN-2-responsive channel.