848354-66-5

中文名稱 NCH-51

英文名稱 PTACH

CAS 848354-66-5

分子式 C20H26N2O2S2

分子量 390.56

MOL 文件 848354-66-5.mol

更新日期 2026/06/02 18:15:55

848354-66-5 結(jié)構(gòu)式

基本信息物理化學(xué)性質(zhì) 安全數(shù)據(jù) 圖譜信息 NCH-51價格(試劑級) 常見問題列表

基本信息

中文別名

化合物PTACH

英文別名

NCH 51
NCH51, >98%
PTACH?, >98%
PTACH (NCH-51)
HDAC Inhibitor XXII, NCH51
HDAC Inhibitor XXII, NCH51 - CAS 848354-66-5 - Calbiochem
Cpd 51, S-[6-(4-Phenyl-2-thiazolylcarbamoyl)hexyl] thioisobutyrate
S-(7-Oxo-7-((4-phenylthiazol-2-yl)amino)-heptyl) 2-methylpropanethioate
2-MethylpropanethioicacidS-[7-oxo-7-[(4-phenyl-2-thiazolyl)amino]heptyl]ester
Propanethioic acid,2-methyl-, S-[7-oxo-7-[(4-phenyl-2-thiazolyl)amino]heptyl] ester

所屬類別

生物化工：激動劑抑制劑

物理化學(xué)性質(zhì)

熔點127-128 °C(Solv: hexane (110-54-3); ethyl acetate (141-78-6))

密度1.181±0.06 g/cm3(Predicted)

儲存條件2-8°C

溶解度在DMSO中的溶解度為26mg/mL

酸度系數(shù)(pKa)9.52±0.50(Predicted)

形態(tài)白色粉末

顏色White to off-white

InChI1S/C20H26N2O2S2/c1-15(2)19(24)25-13-9-4-3-8-12-18(23)22-20-21-17(14-26-20)16-10-6-5-7-11-16/h5-7,10-11,14-15H,3-4,8-9,12-13H2,1-2H3,(H,21,22,23)

InChIKeyMDYDGUOQFUQOGE-UHFFFAOYSA-N

SMILESCC(C)C(=O)SCCCCCCC(=O)Nc1nc(cs1)-c2ccccc2

安全數(shù)據(jù)

危險性符號(GHS) 腐蝕 (GHS05)

GHS05

警示詞危險

危險性描述H318-H413

防范說明P280-P305+P351+P338

危險品標(biāo)志Xi

危險類別碼41

安全說明26-39

WGK Germany3

存儲類別11 - Combustible Solids

圖譜信息

NCH-51(848354-66-5)質(zhì)譜(MS)
NCH-51(848354-66-5)核磁圖(¹HNMR)

NCH-51價格(試劑級)

報價日期	產(chǎn)品編號	產(chǎn)品名稱	CAS號	包裝	價格
2026/06/05	HY-12954	NCH-51 PTACH	848354-66-5	1 mg	560元
2026/06/05	HY-12954	NCH-51 PTACH	848354-66-5	5 mg	1780元
2026/06/05	HY-12954	NCH-51 PTACH	848354-66-5	10 mM * 1 mL in DMSO	1958元

常見問題列表

生物活性

PTACH (NCH-51) 是一種有效的 HDAC 抑制劑，對 HDAC1，HDAC4 和 HDAC6 的 IC50 分別為 48 nM，32 nM 和 41 nM。PTACH 對多種癌細(xì)胞具有強大的生長抑制作用 (EC50 為 1.1-9.1 μM)。

靶點

HDAC1

48 nM (IC ₅₀ )

HDAC4

32 nM (IC ₅₀ )

HDAC6

41 nM (IC ₅₀ )

HIV-1

體外研究

PTACH (compound 51) treatment elevates the levels of acetylated histone H4 and p21 ^WAF1/CIP1 in a dose-dependent manner.
In cancer cell growth inhibition assay, PTACH (compound 51) shows strong activity. PTACH inhibits various cancer cells with EC50 values of 2.3 μM, 9.1 μM, 3.0 μM, 2.6 μM, 1.1 μM, 4.5 μM, 2.4 μM, 5.0 μM, and 4.5 μM for MDA-MB-231, SNB-78, HCT116, NCI-H226, LOX-IMVI, SK-OV-3, RXF-631L, St-4, and DU-145 cells, respectively.
PTACH (NCH-51) augments the HIV-1 production in latently infected OM10.1 cells and such reactivation is associated with a loss of HDAC1 occupancy and subsequent hyperacetylation of histones in nuc-1 at the HIV-1 promoter.

Western Blot Analysis

Cell Line:	HCT 116 cells
Concentration:	1 μM, 5 μM, 25 μM
Incubation Time:	8 hours
Result:	Gave rise to elevated and dose-dependent levels of acetylated histone H4 and p21 ^WAF1/CIP1 .