85079-48-7
85079-48-7 結構式
基本信息
化合物 T10609
toxint-17
Gb 3 toxin
BREVETOXIN3
PUMILIOTOXIN
brevetoxint17
BREVETOXIN PBTX-3
DIHYDROBREVETOXIN B
BKMHDYJRAAJTAD-RXUQWMQDSA-N
42-Hydroxy-42-deoxobrevetoxin B
物理化學性質
安全數(shù)據(jù)
Acute Tox. 4 Inhalation
Acute Tox. 4 Oral
Eye Irrit. 2
Flam. Liq. 2
常見問題列表
IC50: voltage-gated Na + channel
Brevetoxin-3 (PbTx-3)(30-500 nM) produces a shift in activation to more negative membrane potentials whereby single-channel activity is observed under steady-state conditions (maintained depolarization at -50 mV).
Brevetoxin-3 (PbTx-3)(intratracheal instillation; 2.8 μg/kg; gestational days 15-18)?radioactivity is detected in placentas and fetuses within 0.5 hours. Concentrations of brevetoxin equivalents in fetuses are approximately 0.3 ng/g throughout the 48-h post-dosing, resulting in a calculated dose to fetuses of 19 ng/gh. Following brevetoxin infusion, concentration of brevetoxin equivalents in fetuses is 0.1 ng/g, lower than that present in most maternal tissues. .
| Animal Model: | Pregnant CD-1 mice |
| Dosage: | 2.8 μg/kg |
| Administration: | Intratracheal instillation; 2.8 μg/kg; gestational days 15–18 |
| Result: | Demonstrated placental transport of brevetoxin or its metabolites following maternal acute exposure. |