852918-02-6

中文名稱 TCN-201

英文名稱 3-Chloro-4-fluoro-N-[4-[[2-(phenylcarbonyl)hydrazino]carbonyl]benzyl]benzenesulfonamide

CAS 852918-02-6

分子式 C21H17ClFN3O4S

分子量 461.89

MOL 文件 852918-02-6.mol

更新日期 2026/06/03 17:31:20

852918-02-6 結(jié)構(gòu)式

基本信息物理化學(xué)性質(zhì) 安全數(shù)據(jù) 圖譜信息 TCN-201價(jià)格(試劑級(jí)) 常見問(wèn)題列表

基本信息

中文別名

4-[[[(3-氯-4-氟苯基)磺?；鵠氨基]甲基]苯甲酸 2-苯甲?；ｋ?/span>

英文別名

TCN 201
TCN 201-d5
N-[[4-(benzamidocarbamoyl)phenyl]methyl]-3-chloro-4-fluorobenzenesulfonamide
N-(4-(2-benzoylhydrazinecarbonyl)benzyl)-3-chloro-4-fluorobenzenesulfonaMide
4-[[[(3-Chloro-4-fluorophenyl)sulfonyl]aMino]Methyl]benzoic Acid 2-Benzoylhydrazide
3-Chloro-4-fluoro-N-[4-[[2-(phenylcarbonyl)hydrazino]carbonyl]benzyl]benzenesulfonamide
Benzoic acid, 4-[[[(3-chloro-4-fluorophenyl)sulfonyl]amino]methyl]-, 2-benzoylhydrazide
3-Chloro-4-fluoro-N-[(4-{[2-(phenylcarbonyl)hydrazino]carbonyl}phenyl)methyl]benzenesulfonamide
TCN-201 N-(4-(2-benzoylhydrazinecarbonyl)benzyl)-3-chloro-4- fluorobenzenesulfonaMide

所屬類別

生物：小分子化合物

物理化學(xué)性質(zhì)

儲(chǔ)存條件2-8°C

溶解度DMSO：可溶，5mg/mL（澄清溶液）

形態(tài)粉末

顏色白色至米色

InChI1S/C21H17ClFN3O4S/c22-18-12-17(10-11-19(18)23)31(29,30)24-13-14-6-8-16(9-7-14)21(28)26-25-20(27)15-4-2-1-3-5-15/h1-12,24H,13H2,(H,25,27)(H,26,28)

InChIKeyFYIBXBFDXNPBSF-UHFFFAOYSA-N

SMILESFc1ccc(cc1Cl)S(=O)(=O)NCc2ccc(cc2)C(=O)NNC(=O)c3ccccc3

安全數(shù)據(jù)

危險(xiǎn)性符號(hào)(GHS) 有害 (GHS07)

GHS07

警示詞警告

危險(xiǎn)性描述H315-H319-H335-H336

防范說(shuō)明P261-P264-P271-P280-P302+P352-P305+P351+P338

危險(xiǎn)品標(biāo)志Xi

危險(xiǎn)類別碼22-36/37/38

安全說(shuō)明26-36/37/39

WGK Germany3

存儲(chǔ)類別11 - Combustible Solids

危險(xiǎn)性類別Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

圖譜信息

TCN-201(852918-02-6)核磁圖(¹HNMR)

TCN-201價(jià)格(試劑級(jí))

報(bào)價(jià)日期	產(chǎn)品編號(hào)	產(chǎn)品名稱	CAS號(hào)	包裝	價(jià)格
2026/06/05	HY-13457	TCN 201	852918-02-6	1 mg	242元
2026/06/05	HY-13457	TCN 201	852918-02-6	5 mg	605元
2026/06/05	HY-13457	TCN-201 TCN 201	852918-02-6	10mg	1100元

常見問(wèn)題列表

生物活性

TCN 201 是一種有效的，選擇性和非競(jìng)爭(zhēng)性的 GluN1/GluN2A NMDA 受體拮抗劑，pIC50 值為 6.8。與 GluN1/GluN2B NMDA 受體 (pIC50<4.3) 相比，TCN 201 對(duì) GluN1/GluN2A NMDA 受體具有選擇性。

靶點(diǎn)

pIC50: 6.8 (GluN1/GluN2A NMDA receptor)

體外研究

TCN 201 (compound 1) is selective for GluN1/GluN2A NMDAR over GluN1/GluN2B NMDAR, with pIC ₅₀ s of 6.8 and <4.3, respectively.
TCN 201 (10 μM) produces only slight inhibition of GluN1/GluN2B NMDAR-mediated currents in oocytes.
TCN 201 (10-30 μM) antagonism of NMDAR-mediated responses is both subtype- and glycine-dependent and more potent than TCN 213 in oocytes.
TCN 201 (0.1-100 μM) does not produce complete block of NMDAR-mediated responses in oocytes.
TCN 201 (10 μM) antagonism of NMDAR-mediated currents shows a negative correlation with their ifenprodil sensitivity in rat cortical neurons.
TCN 201 (1-9 μM) suppresses cortical spreading depression (CSD) in chick retina.

體內(nèi)研究

TCN-201 (10 mg/kg; i.p.) is ineffective in CSD blood-oxygen level-dependent (BOLD) response in rats.