853220-52-7
853220-52-7 結構式
基本信息
WNT信號激活劑(BML-284)
WNT AGONIST 1 (CID11210285 鹽酸鹽)
WNT AGONIST 1 CID11210285 鹽酸鹽 BML-284
2-氨基-4-[[3,4-(亞甲二氧基)芐基]氨基]-6-(3-甲氧基苯基)嘧啶
N4-(苯并[D][1,3]二氧雜環(huán)戊烯-5-基甲基)-6-(3-甲氧基苯基)嘧啶-2,4-二胺
-284
AMBMP
BML-284
CS-2376
Wnt Agonist
2-Amino-4-[3
Wnt agonist 1
Wnt Agonist I
BML-284 (BML 284
物理化學性質
| 報價日期 | 產品編號 | 產品名稱 | CAS號 | 包裝 | 價格 |
| 2025/12/22 | HY-19987 | WNT AGONIST 1 (CID11210285 鹽酸鹽) BML-284 | 853220-52-7 | 5mg | 660元 |
| 2025/12/22 | HY-19987 | WNT AGONIST 1 (CID11210285 鹽酸鹽) BML-284 | 853220-52-7 | 10mM * 1mLin DMSO | 726元 |
| 2025/12/22 | HY-19987 | WNT AGONIST 1 (CID11210285 鹽酸鹽) BML-284 | 853220-52-7 | 10mg | 860元 |
常見問題列表
EC50: 700 nM (TCF-dependent transcriptional activity)
BML-284 (10 μM; 24 hours) significantly increases the migration and invasion of both MNK45 and AGS cells and partially restores the migratory and invasive abilities of cells inhibited by pizotifen.BML-284 (10 μM; 24 hours) induces the expression of β-catenin significantly when compared with the NC group. It also partially reverses the effects induced by pizotifen on E-cadherin and N-cadherin expression in MNK45 and AGS cells compared with the pizotifen-treated group.
Western Blot Analysis
| Cell Line: | Human gastric cancer cell lines MNK45 and AGS [1] |
| Concentration: | 10 μM |
| Incubation Time: | 24 hours |
| Result: | Induced β-catenin expression and reserved E-cadherin and N-cadherin expression in MNK45 and AGS cells. |
BML-284 (10 ng) combines with Pyrimethanil (4 mg/L) could partially rescue the malformed phenotype and cardiac defects induced by Pyrimethanil in Tg (myl7:EGFP) transgenic embryos at 5.5 hpf are transferred into plates with 20 embryos.