853220-52-7

中文名稱 WNT AGONIST 1 (CID11210285 鹽酸鹽)

英文名稱 Wnt Agonist

CAS 853220-52-7

分子式 C19H18N4O3

分子量 350.37

MOL 文件 853220-52-7.mol

更新日期 2026/05/25 13:08:14

853220-52-7 結(jié)構(gòu)式

基本信息物理化學(xué)性質(zhì) 安全數(shù)據(jù) 圖譜信息 WNT AGONIST 1 (CID11210285 鹽酸鹽)價(jià)格(試劑級) 常見問題列表

基本信息

中文別名

化合物WNT AGONIST 1
WNT信號激活劑(BML-284)
WNT AGONIST 1 (CID11210285 鹽酸鹽)
WNT AGONIST 1 CID11210285 鹽酸鹽 BML-284
2-氨基-4-[[3,4-(亞甲二氧基)芐基]氨基]-6-(3-甲氧基苯基)嘧啶
N4-(苯并[D][1,3]二氧雜環(huán)戊烯-5-基甲基)-6-(3-甲氧基苯基)嘧啶-2,4-二胺

英文別名

BML
-284
AMBMP
BML-284
CS-2376
Wnt Agonist
2-Amino-4-[3
Wnt agonist 1
Wnt Agonist I
BML-284 (BML 284

所屬類別

生物化工：激動劑抑制劑

物理化學(xué)性質(zhì)

沸點(diǎn)623.4±65.0 °C(Predicted)

密度1.353±0.06 g/cm3(Predicted)

儲存條件2-8°C

溶解度在DMSO中的溶解度為20mg/mL，澄清

酸度系數(shù)(pKa)6.62±0.10(Predicted)

形態(tài)淡黃色粘稠固體

顏色白色至米色

InChI1S/C19H18N4O3/c1-24-14-4-2-3-13(8-14)15-9-18(23-19(20)22-15)21-10-12-5-6-16-17(7-12)26-11-25-16/h2-9H,10-11H2,1H3,(H3,20,21,22,23)

InChIKeyFABQUVYDAXWUQP-UHFFFAOYSA-N

SMILESN(Cc3cc4c(cc3)OCO4)c1nc(nc(c1)c2cc(ccc2)OC)N

安全數(shù)據(jù)

危險(xiǎn)性符號(GHS) 有害 (GHS07)

GHS07

警示詞警告

危險(xiǎn)性描述H315-H319

防范說明P305+P351+P338

危險(xiǎn)品標(biāo)志Xi

危險(xiǎn)類別碼36/38

安全說明26-39

WGK Germany3

存儲類別11 - Combustible Solids

危險(xiǎn)性類別Eye Irrit. 2
Skin Irrit. 2

圖譜信息

WNT AGONIST 1 (CID11210285 鹽酸鹽)(853220-52-7)核磁圖(¹HNMR)

WNT AGONIST 1 (CID11210285 鹽酸鹽)價(jià)格(試劑級)

報(bào)價(jià)日期	產(chǎn)品編號	產(chǎn)品名稱	CAS號	包裝	價(jià)格
2026/06/05	HY-19987R	WNT AGONIST 1 (CID11210285 鹽酸鹽) BML-284 (Standard)	853220-52-7	5 mg	1650元
2026/06/05	HY-19987R	WNT AGONIST 1 (CID11210285 鹽酸鹽) BML-284 (Standard)	853220-52-7	10 mg	2475元
2026/06/05	HY-19987	WNT AGONIST 1 (CID11210285 鹽酸鹽) BML-284	853220-52-7	5mg	660元

常見問題列表

生物活性

BML-284 是一種有效的細(xì)胞通透性 Wnt 信號激活劑。BML-284 誘導(dǎo) TCF 依賴的轉(zhuǎn)錄活性，其 EC50>700 nM 。

靶點(diǎn)

EC50: 700 nM (TCF-dependent transcriptional activity)

體外研究

BML-284 (10 μM; 24 hours) significantly increases the migration and invasion of both MNK45 and AGS cells and partially restores the migratory and invasive abilities of cells inhibited by pizotifen.BML-284 (10 μM; 24 hours) induces the expression of β-catenin significantly when compared with the NC group. It also partially reverses the effects induced by pizotifen on E-cadherin and N-cadherin expression in MNK45 and AGS cells compared with the pizotifen-treated group.

Western Blot Analysis

Cell Line:	Human gastric cancer cell lines MNK45 and AGS ^[1]
Concentration:	10 μM
Incubation Time:	24 hours
Result:	Induced β-catenin expression and reserved E-cadherin and N-cadherin expression in MNK45 and AGS cells.

體內(nèi)研究

BML-284 (10 ng) combines with Pyrimethanil (4 mg/L) could partially rescue the malformed phenotype and cardiac defects induced by Pyrimethanil in Tg (myl7:EGFP) transgenic embryos at 5.5 hpf are transferred into plates with 20 embryos.