85375-15-1

中文名稱 1 - (4,4 - 二苯基-3 - 丁烯基)- 3 -哌啶鹽酸鹽

英文名稱 1-(4,4-DIPHENYL-3-BUTENYL)-3-PIPERIDINECARBOXYLIC ACID HYDROCHLORIDE

CAS 85375-15-1

分子式 C22H26ClNO2

分子量 371.9

MOL 文件 85375-15-1.mol

85375-15-1 結(jié)構(gòu)式

基本信息物理化學(xué)性質(zhì) 安全數(shù)據(jù) 圖譜信息 1 - (4,4 - 二苯基-3 - 丁烯基)- 3 -哌啶鹽酸鹽價(jià)格(試劑級(jí)) 常見問題列表

基本信息

中文別名

4-二苯基-3-丁烯基)-3-哌啶鹽酸鹽
1-(4,4-二苯基-3-丁烯-1-基)-3-哌啶甲酸鹽酸鹽
1 - (4,4 - 二苯基-3 - 丁烯基)- 3 -哌啶鹽酸鹽

英文別名

skf-89976a
SKF89976AHCl
SKF 89976A HYDROCHLORIDE
l-SKF89976A hydrochloride
d,l-SKF89976A hydrochloride
1-(4,4-DIPHENYL-3-BUTENYL)-3-PIPERIDINECARBOXYLIC ACID HYDROCHLORIDE
1-(4,4-Diphenylbut-3-en-1-yl)piperidine-3-carboxylic acid hydrochloride
1-(4,4-Diphenyl-3-buten-1-yl)-3-piperidinecarboxylic acid hydrochloride

所屬類別

生物化工：激動(dòng)劑抑制劑

物理化學(xué)性質(zhì)

儲(chǔ)存條件Inert atmosphere,2-8°C

溶解度DMSO: 20 mg/mL, soluble

溶解度在DMSO中的溶解度為20 mg/mL

形態(tài)solid

顏色white

InChI1S/C22H25NO2.ClH/c24-22(25)20-13-7-15-23(17-20)16-8-14-21(18-9-3-1-4-10-18)19-11-5-2-6-12-19;/h1-6,9-12,14,20H,7-8,13,15-17H2,(H,24,25);1H

InChIKeySNGGBKYQZVAQKA-UHFFFAOYSA-N

SMILESCl[H].OC(=O)C1CCCN(CC\C=C(/c2ccccc2)c3ccccc3)C1

安全數(shù)據(jù)

WGK Germany3

RTECS號(hào)TM6241000

存儲(chǔ)類別11 - Combustible Solids

圖譜信息

1 - (4,4 - 二苯基-3 - 丁烯基)- 3 -哌啶鹽酸鹽(85375-15-1)核磁圖(¹HNMR)

1 - (4,4 - 二苯基-3 - 丁烯基)- 3 -哌啶鹽酸鹽價(jià)格(試劑級(jí))

報(bào)價(jià)日期	產(chǎn)品編號(hào)	產(chǎn)品名稱	CAS號(hào)	包裝	價(jià)格
2026/06/05	HY-100228A	1 - (4,4 - 二苯基-3 - 丁烯基)- 3 -哌啶鹽酸鹽 SKF89976A hydrochloride	85375-15-1	5mg	660元
2026/06/05	HY-100228A	1 - (4,4 - 二苯基-3 - 丁烯基)- 3 -哌啶鹽酸鹽 SKF89976A hydrochloride	85375-15-1	10mM * 1mLin DMSO	726元
2026/06/05	HY-100228A	1 - (4,4 - 二苯基-3 - 丁烯基)- 3 -哌啶鹽酸鹽 SKF89976A hydrochloride	85375-15-1	10mg	990元

常見問題列表

生物活性

SKF89976A hydrochloride 是一種選擇性 GABA 轉(zhuǎn)運(yùn)蛋白 GAT-1 抑制劑，作用于 CHO 細(xì)胞中的 GAT-1，GAT-2 和 GAT-3，IC50 分別為 0.28 μM，137.34 μM 和 202.8 μM。

靶點(diǎn)

IC50: 0.28 μM (GAT-1), 137.34 μM (GAT-2), 202.8 μM (GAT-3)

體外研究

SKF89976A has a weak antiallodynic action. SKF89976A weakly inhibits serotonin transporter (SERT), noradrenaline transporter (NET), and dopamine transporter (DAT) in chinese hamster ovary (CHO) cells stably expressing each transporter using a substrate uptake assay, with IC ₅₀ values of 3514 , 202.13, and 728.8, respectively. SKF89976A is a GABA-transport blocker. GABA (1 mM) elicited an inward current that is completely suppressed by the GABA transport inhibitors tiagabine (10 μM) and SKF89976A (100 μM), but is unaffected by 100 μM picrotoxin. 100 μM SKF 89976-A is known to block the transport of GABA into cells, completely eliminated the GABA-elicited current in a reversible fashion. SKF89976A is a nontransportable blockers of GAT-1. SKF89976-A also suppresses baseline inward currents that likely result from tonic GAT activation by background GABA. SKF89976A (100 μM) reversibly reduces GAT currents in every studied cell by 67.9±4.4% (n=19). Intracellular perfusion of 20 μM SKF89976-A progressively reduced and blocked GABA-induced GAT currents without blocking GABAAR-mediated currents (n=4).

體內(nèi)研究

SKF89976A produces a weak antiallodynic response when administered i.v. (0.3 mg/kg). The i.t. injection of SKF89976A dose-dependently ameliorates the reduction in the withdrawal threshold in PSL model mice.