855746-98-4
中文名稱(chēng)
苦參醇
英文名稱(chēng)
Kurarinol
CAS
855746-98-4
分子式
C26H32O7
分子量
456.53
MOL 文件
855746-98-4.mol
855746-98-4 結(jié)構(gòu)式
基本信息
英文別名
4'',5''-Dihydro-5''-hydroxysophoraflavanone G 5-methyl ether2-(2,4-dihydroxy-phenyl)-7-hydroxy-8-[2-(3-hydroxy-3-methyl-butyl)-3-methyl-but-3-enyl]-5-methoxy-chroman-4-one
(2S)-2-(2,4-Dihydroxyphenyl)-2,3-dihydro-7-hydroxy-8-[(2R)-5-hydroxy-5-methyl-2-(1-methylethenyl)hexyl]-5-methoxy-4H-1-benzopyran-4-one
4H-1-Benzopyran-4-one, 2-(2,4-dihydroxyphenyl)-2,3-dihydro-7-hydroxy-8-[(2R)-5-hydroxy-5-methyl-2-(1-methylethenyl)hexyl]-5-methoxy-, (2S)-
物理化學(xué)性質(zhì)
熔點(diǎn)166-169 °C
沸點(diǎn)683.8±55.0 °C(Predicted)
密度1.250±0.06 g/cm3(Predicted)
溶解度Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
酸度系數(shù)(pKa)7.54±0.40(Predicted)
形態(tài)粉末
常見(jiàn)問(wèn)題列表
生物活性
Kurarinol 是一種黃烷酮，在 Sophora flavescens 根中被發(fā)現(xiàn)。Kurarinol 是一種競(jìng)爭(zhēng)性的酪氨酸酶 (tyrosinase) 抑制劑，對(duì)蘑菇型酪氨酸酶作用的 IC50 為 0.1 μM 。靶點(diǎn)
IC50: 0.1 μM (mushroom tyrosinase)
體外研究
Kurarinol manifests relatively low cytotoxic activity (EC
50
>30 μM).
Kurarinol inhibits production of melanin in S. bikiniensis without affecting the growth of microorganism.
Kurarinol induces hepatocellular carcinoma cell apoptosis through suppressing cellular signal transducer and activator of transcription 3 signaling (STAT3).
體內(nèi)研究
Kurarinol (20 mg/kg; p.o.; daily; for 3 days) reduced serum lipid levels in high-Cholesterol diet induced hyperlipidemic rats.
| Animal Model: | Male Sprague-Dawley rats (120-130g), hypercholesterolemic models |
| Dosage: | 20 mg/kg |
| Administration: | Oral administration, daily, for 3 days |
| Result: | Decreased serum TC, TG, and LDL-C levels. |