99119-73-0
99119-73-0 結(jié)構(gòu)式
基本信息
苦參新醇 C
2-(2,4-Dihydroxyphenyl)-3,5,7-trihydroxy-8-[(2R)-5-methyl-2-(1-methylethenyl)-4-hexenyl]-4H-1-benzopyran-4-one
4H-1-Benzopyran-4-one, 2-(2,4-dihydroxyphenyl)-3,5,7-trihydroxy-8-[(2R)-5-methyl-2-(1-methylethenyl)-4-hexen-1-yl]-
物理化學(xué)性質(zhì)
常見問(wèn)題列表
Kushenol C dose-dependently suppresses the production of inflammatory mediators, including NO, PGE2, IL-6, IL1β, MCP-1, and IFN-β in LPS-stimulated RAW264.7 macrophages. Kushenol C (50-100 μM;) significantly decreases the phosphorylation of both STAT1 molecules and STAT6 in a dose-dependent manner in LPS-stimulated RAW264.7 cells.
Kushenol C upregulates the expression of HO-1 and its activities in the LPS-stimulated RAW264.7 macrophages. In HaCaT cells, Kushenol C prevents DNA damage and cell death by upregulating the endogenous antioxidant defense system involving glutathione, superoxide dismutase, and catalase, which prevents reactive oxygen species production from tert-butyl hydroperoxide (tBHP)-induced oxidative stress in HaCaT cells.
Kushenol C inhibits BChE and AChE with IC
50
s of 54.86 and 33.13 μM.