858474-14-3

中文名稱 2-(P-METHOXYPHENYL)-Α-2-PIPERIDYL-4-QUINOLINEMETHANOL DIHYDROCHLORIDE

英文名稱 2-(4-Methoxyphenyl)-α-2-piperidinyl-4-quinolinemethanol Dihydrochloride

CAS 858474-14-3

分子式 C22H25ClN2O2

分子量 384.9

MOL 文件 858474-14-3.mol

858474-14-3 結(jié)構(gòu)式

基本信息物理化學(xué)性質(zhì) 安全數(shù)據(jù) 2-(P-METHOXYPHENYL)-Α-2-PIPERIDYL-4-QUINOLINEMETHANOL DIHYDROCHLORIDE價(jià)格(試劑級(jí)) 常見問題列表

基本信息

中文別名

化合物 T16352
2-(P-METHOXYPHENYL)-Α-2-PIPERIDYL-4-QUINOLINEMETHANOL DIHYDROCHLORIDE

英文別名

NSC23925
NSC-23925
2-(P-METHOXYPHENYL)-Α-2-PIPERIDYL-4-QUINOLINEMETHANOL DIHYDROCHLORIDE
2-(4-Methoxyphenyl)-α-2-piperidinyl-4-quinolinemethanol Dihydrochloride
4-Quinolinemethanol, 2-(4-methoxyphenyl)-α-2-piperidinyl-, hydrochloride
(2-(4-Methoxyphenyl)quinolin-4-yl)(piperidin-2-yl)methanol dihydrochloride
[2-(4-Methoxyphenyl)4-quinolinyl]-(piperidin-2-y)-methanol dihydrochloride

物理化學(xué)性質(zhì)

儲(chǔ)存條件room temp

溶解度H2O：可溶5mg/mL（澄清溶液）

形態(tài)粉末

顏色白色至米色

水溶解性H2O: 5mg/mL (clear solution)

InChI1S/C22H24N2O2.2ClH/c1-26-16-11-9-15(10-12-16)21-14-18(17-6-2-3-7-19(17)24-21)22(25)20-8-4-5-13-23-20;;/h2-3,6-7,9-12,14,20,22-23,25H,4-5,8,13H2,1H3;2*1H

InChIKeyWGWOQHWZXLGPNG-UHFFFAOYSA-N

SMILESCl.Cl.COc1ccc(cc1)-c2cc(C(O)C3CCCCN3)c4ccccc4n2

安全數(shù)據(jù)

危險(xiǎn)性符號(hào)(GHS) 有毒 (GHS06)

GHS06

警示詞危險(xiǎn)

危險(xiǎn)性描述H301

防范說(shuō)明P264-P270-P301+P310-P405-P501

危險(xiǎn)品標(biāo)志T

危險(xiǎn)類別碼25

安全說(shuō)明45

危險(xiǎn)品運(yùn)輸編號(hào)UN 2811 6.1 / PGIII

WGK Germany3

存儲(chǔ)類別6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects

危險(xiǎn)性類別Acute Tox. 3 Oral

2-(P-METHOXYPHENYL)-Α-2-PIPERIDYL-4-QUINOLINEMETHANOL DIHYDROCHLORIDE價(jià)格(試劑級(jí))

報(bào)價(jià)日期	產(chǎn)品編號(hào)	產(chǎn)品名稱	CAS號(hào)	包裝	價(jià)格
2026/06/05	HY-19626	2-(P-METHOXYPHENYL)-Α-2-PIPERIDYL-4-QUINOLINEMETHANOL DIHYDROCHLORIDE NSC23925	858474-14-3	5mg	1100元
2026/06/05	HY-19626	2-(P-METHOXYPHENYL)-Α-2-PIPERIDYL-4-QUINOLINEMETHANOL DIHYDROCHLORIDE NSC23925	858474-14-3	10mg	1900元
2026/06/05	HY-19626	2-(P-METHOXYPHENYL)-Α-2-PIPERIDYL-4-QUINOLINEMETHANOL DIHYDROCHLORIDE NSC23925	858474-14-3	25 mg	4200元

常見問題列表

生物活性

NSC23925 是一種新型的，有選擇性且有效的 P-糖蛋白 (Pgp) 抑制劑。

靶點(diǎn)

P-glycoprotein

體外研究

NSC23925 is a novel, selective and effective P-glycoprotein (Pgp) inhibitor. SKOV-3 cells with long-term exposure of 1 μM NSC23925 show stable growth in culture medium. NSC23925 specifically inhibits Pgp overexpression to prevent the emergence of paclitaxel resistance during paclitaxel treatment. NSC23925 reverses chemoresistance in a wide variety of tumor types where Multidrug resistance 1 (MDR1) is highly expressed. Maximal reversal of MDR is typically seen in NSC23925 doses between 0.5 and 1 μM. The IC ₅₀ for NSC23925 is 8 μM in SKOV-3/SKOV-3 _TR and 25 μM in OVCAR8/OVCAR8 _TR cell lines, whereas the mean concentration of NSC23925 required for maximal reversal of resistance in SKOV-3 _TR or OVCAR8 _TR to cytotoxic drugs is 0.5 μM to 1 μM.

體內(nèi)研究