861214-33-7

中文名稱 5'-Fluoro-1H,1'H-[2,3']biindolylidene-3,2'dione3-oxime

英文名稱 5'-Fluoro-1H,1'H-[2,3']biindolylidene-3,2'dione3-oxime

CAS 861214-33-7

分子式 C16H10FN3O2

分子量 295.27

MOL 文件 861214-33-7.mol

更新日期 2023/03/20 15:41:21

861214-33-7 結構式

基本信息物理化學性質(zhì) 安全數(shù)據(jù) 圖譜信息 5'-Fluoro-1H,1'H-[2,3']biindolylidene-3,2'dione3-oxime價格(試劑級) 常見問題列表

基本信息

中文別名

化合物5'-FLUOROINDIRUBINOXIME
5'-氟-3-(肟基)-[2,3'-雙吲哚亞基]-2'-酮

英文別名

5'-FIO
-Fluoroindirubinoxime
5'-Fluoroindirubinoxime
5'-Fluoro-1H,1'H-[2,3']biindolylidene-3,2'dione3-oxime
2H-Indol-2-one, 3-[1,3-dihydro-3-(hydroxyimino)-2H-indol-2-ylidene]-5-fluoro-1,3-dihydro-

物理化學性質(zhì)

沸點528.3±50.0 °C(Predicted)

密度1.57±0.1 g/cm3(Predicted)

儲存條件Keep in dark place,Sealed in dry,Store in freezer, under -20°C

溶解度DMSO : 83.33 mg/mL (282.22 mM; Need ultrasonic)

酸度系數(shù)(pKa)8.48±0.20(Predicted)

形態(tài)粉末

顏色Light brown to black

安全數(shù)據(jù)

危險性符號(GHS) 有害 (GHS07)

GHS07

警示詞警告

危險性描述H315-H319

防范說明P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313

圖譜信息

5'-Fluoro-1H,1'H-[2,3']biindolylidene-3,2'dione3-oxime(861214-33-7)核磁圖(¹HNMR)

5'-Fluoro-1H,1'H-[2,3']biindolylidene-3,2'dione3-oxime價格(試劑級)

報價日期	產(chǎn)品編號	產(chǎn)品名稱	CAS號	包裝	價格
2026/07/06	S0550	5'-Fluoro-1H,1'H-[2,3']biindolylidene-3,2'dione3-oxime 5'-Fluoroindirubinoxime	861214-33-7	5mg	3497.13元
2026/07/06	S0550	5'-Fluoro-1H,1'H-[2,3']biindolylidene-3,2'dione3-oxime 5'-Fluoroindirubinoxime	861214-33-7	25mg	10556.9元
2026/06/05	HY-103464	5'-Fluoroindirubinoxime	861214-33-7	1 mg	678元

常見問題列表

生物活性

5'-Fluoroindirubinoxime (compound 13) 是Indirubin (HY-N0117) 的衍生物，是FLT3 的抑制劑，其IC50 值為15 nM。

靶點

15 nM (FLT3).

體外研究

5'-Fluoroindirubinoxime (5’-FIO, compound 13) exhibits IC ₅₀ values of 1.53 μM and 1.27 μM for VEGFR2 and Aurora A, respectively.
5'-Fluoroindirubinoxime (5’-FIO) exhibits IC ₅₀ values of 12.2 μM, 2.1 μM, 3.4 μM and 5.1 μM in A549, SNU-638, HT-1080 and RK3E-ras cancer cells, respectively. 5'-Fluoroindirubinoxime (5’-FIO) induces the apoptosis in RK3E-ras cells.

體內(nèi)研究

5'-Fluoroindirubinoxime (5’-FIO, 10 μmol/L/100 μL (~2.95 mg/mL) every other day beginning on day 6, S.C..) exhibits significant anti-tumor activity in rats.

Animal Model:	Rat tumor model based RK3E-ras cells.
Dosage:	S.C..
Administration:	10 μmol/L/100 μL (~2.95 mg/mL) every other day beginning on day 6.
Result:	Effectively inhibited tumor growth.