864082-48-4
中文名稱
化合物 T27479
英文名稱
GSK466317A
CAS
864082-48-4
分子式
C21H16ClF3N4O2
分子量
448.83
MOL 文件
864082-48-4.mol
864082-48-4 結(jié)構(gòu)式
物理化學(xué)性質(zhì)
沸點713.4±60.0 °C(Predicted)
密度1.485±0.06 g/cm3(Predicted)
酸度系數(shù)(pKa)11.54±0.40(Predicted)
應(yīng)用領(lǐng)域
用途一
GSK466317A is a GRK2 inhibitor. GRK2 has been directly implicated in the progression of heart failure. Selective inhibitors of individual subfamilies of G protein-coupled receptor kinases (GRKs) would serve as useful chemical probes as well as leads for therapeutic applications ranging from heart failure to Parkinson's disease.