871700-24-2
中文名稱(chēng)
曲美替尼中間體
英文名稱(chēng)
3-cyclopropyl-1-(2-fluoro-4-iodophenyl)-5-hydroxy-6,8-diMethylpyrido[2,3-d]pyriMidine-2,4,7(1H,3H,8H)-trione
CAS
871700-24-2
分子式
C18H15FIN3O4
分子量
483.23
MOL 文件
871700-24-2.mol
更新日期
2026/07/22 13:57:36
871700-24-2 結(jié)構(gòu)式
基本信息
中文別名
曲美替尼INT曲美替尼中間體
GSK1120212 中間體7
3-環(huán)丙基-1-(2-氟-4-碘苯基)-5-羥基-6,8-二甲基-1H,8H-吡啶并[2,3-D]嘧啶-2,4,7-三酮
3-環(huán)丙基-1-(2-氟-4-碘苯基)-5-羥基-6,8-二甲基吡啶并[2,3-D]嘧啶-2,4,7-(1H,3H,8H)-三酮
3-環(huán)丙基-1-(2-氟-4-碘-苯基)-5-羥基-6,8-二甲基吡啶[2,3-右旋]嘧啶-2,4,7-(1H,3H,8H)-三酮
英文別名
CB42623933Trametinib INT
cyclopropylthiadiazolamine
3-Cyclopropyl-1-(2-fluoro-4-iodophenyl)-5-hydroxy-6,8-dimethylpyrido[2,3-d]pyrimidine-2,4,7(1H
3-cyclopropyl-1-(2-fluoro-4-iodophenyl)-5-hydroxy-6,8-diMethylpyrido[2,3-d]pyriMidine-2,4,7(1H,3H,8H
3-Cyclopropyl-1-(2-fluoro-4-iodophenyl)-5-hydroxy-6,8-dimethyl-1H,8H-pyrido[2,3-d]pyrimidine-2,4,7-trione
3-cyclopropyl-1-(2-fluoro-4-iodophenyl)-5-hydroxy-6,8-diMethylpyrido[2,3-d]pyriMidine-2,4,7(1H,3H,8H)-trione
Pyrido[2,3-d]pyrimidine-2,4,7(1H,3H,8H)-trione, 3-cyclopropyl-1-(2-fluoro-4-iodophenyl)-5-hydroxy-6,8-dimethyl-
所屬類(lèi)別
醫(yī)藥中間體：原料藥中間體物理化學(xué)性質(zhì)
沸點(diǎn)518.2±60.0 °C(Predicted)
密度1.94±0.1 g/cm3(Predicted)
儲(chǔ)存條件2-8°C(protect from light)
溶解度可溶于DMSO（少許）、甲醇（少許）
酸度系數(shù)(pKa)4.50±1.00(Predicted)
形態(tài)固體
顏色白色至灰白色
InChIInChI=1S/C18H15FIN3O4/c1-8-14(24)13-15(21(2)16(8)25)23(12-6-3-9(20)7-11(12)19)18(27)22(17(13)26)10-4-5-10/h3,6-7,10,24H,4-5H2,1-2H3
InChIKeyMHHFXMZMCYWCJQ-UHFFFAOYSA-N
SMILESC1(=O)N(C2CC2)C(=O)C2C(O)=C(C)C(=O)N(C)C=2N1C1=CC=C(I)C=C1F
