875051-72-2

中文名稱 2 - 吡啶甲酰胺,6 - 氨基-N-甲基-5 - (2,3,5 - 三氯苯基) -

英文名稱 PF-01247324

CAS 875051-72-2

分子式 C13H10Cl3N3O

分子量 330.6

MOL 文件 875051-72-2.mol

更新日期 2026/07/13 13:11:17

875051-72-2 結構式

基本信息物理化學性質安全數(shù)據(jù) 圖譜信息 2 - 吡啶甲酰胺,6 - 氨基-N-甲基-5 - (2,3,5 - 三氯苯基) -價格(試劑級) 常見問題列表

基本信息

中文別名

化合物PF01247324
2 - 吡啶甲酰胺,6 - 氨基-N-甲基-5 - (2,3,5 - 三氯苯基) -

英文別名

133786
CS-2577
PF-1247324
PF-01247324
PF01247324
PF 01247324
6-amino-N-methyl-5-(2,3,5-trichlorophenyl)picolinamide
6-AMINO-N-METHYL-5-(2,3,5-TRICHLOROPHENYL)PYRIDINE-2-CARBOXAMIDE
2-PyridinecarboxaMide, 6-aMino-N-Methyl-5-(2,3,5-trichlorophenyl)-
6-AMINO-5-(2,3,5-TRICHLORO-PHENYL)-PYRIDINE-2-CARBOXYLIC ACID METHYLAMIDE

所屬類別

生物化工：激動劑抑制劑

物理化學性質

沸點477.7±45.0 °C(Predicted)

密度1.460±0.06 g/cm3(Predicted)

儲存條件room temp

溶解度DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml; Ethanol:PBS (pH 7.2) (1:4): 0.2 mg/ml

酸度系數(shù)(pKa)6.56±0.46(Predicted)

形態(tài)粉末

顏色白色至米色

InChI1S/C13H10Cl3N3O/c1-18-13(20)10-3-2-7(12(17)19-10)8-4-6(14)5-9(15)11(8)16/h2-5H,1H3,(H2,17,19)(H,18,20)

InChIKeyHPIUHDCRVYDAEJ-UHFFFAOYSA-N

SMILESClc1c(cc(cc1c2c(nc(cc2)C(=O)NC)N)Cl)Cl

安全數(shù)據(jù)

危險性符號(GHS) 有毒 (GHS06)

GHS06

警示詞危險

危險性描述H301-H315-H319-H335

防范說明P301+P310+P330-P302+P352-P305+P351+P338

危險品運輸編號UN 2811 6.1 / PGIII

WGK GermanyWGK 3

存儲類別6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects

危險性類別Acute Tox. 3 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

圖譜信息

2 - 吡啶甲酰胺,6 - 氨基-N-甲基-5 - (2,3,5 - 三氯苯基) -(875051-72-2)核磁圖(¹HNMR)

2 - 吡啶甲酰胺,6 - 氨基-N-甲基-5 - (2,3,5 - 三氯苯基) -價格(試劑級)

報價日期	產(chǎn)品編號	產(chǎn)品名稱	CAS號	包裝	價格
2026/06/05	HY-101383	2 - 吡啶甲酰胺,6 - 氨基-N-甲基-5 - (2,3,5 - 三氯苯基) - PF-01247324	875051-72-2	5mg	700元
2026/06/05	HY-101383	2 - 吡啶甲酰胺,6 - 氨基-N-甲基-5 - (2,3,5 - 三氯苯基) - PF-01247324	875051-72-2	10mM * 1mLin DMSO	770元
2026/06/05	HY-101383	2 - 吡啶甲酰胺,6 - 氨基-N-甲基-5 - (2,3,5 - 三氯苯基) - PF-01247324	875051-72-2	10mg	1200元

常見問題列表

生物活性

PF-01247324是選擇性且有口服活性的Nav1.8通道阻斷物，對人類重組Nav1.8 的IC50值為196 nM。

靶點

IC50: 196 nM (hNa _v 1.8)

體外研究

PF-01247324 inhibits native tetrodotoxin-resistant (TTX-R) currents in human dorsal root ganglion (DRG) neurons (IC ₅₀ =331 nM) and in recombinantly expressed h Na _v 1.8 channels (IC ₅₀ =196 nM), with 50-fold selectivity over recombinantly expressed TTX-R hNav1.5 channels (IC ₅₀ =10 μM) and 65-100-fold selectivity over TTX-sensitive (TTX-S) channels (IC ₅₀ =10-18 μM). In vitro current clamp shows that PF-01247324 reduces excitability in both rat and human DRG neurons and also alters the waveform of the action potential.

體內研究

Experiments n rodents demonstrates efficacy in both inflammatory and neuropathic pain models. PF-01247324 reduces phase 2 flinching by 37% at 100 mg/kg. There is a significant effect of 30 mg/kg of PF-01247324 in the rat model carrageenan-induced thermal hyperalgesia and in CFA-induced mechanical hyperalgesia at exposures of 0.218 and 0.126 μM respectively. Mice that received PF-01247324 shows significant improvements in motor coordination and cerebellar-like symptoms compared to control.