88847-89-6
中文名稱
8-OH-脫氧鳥嘌呤
英文名稱
8-OXO-2'-DEOXYGUANOSINE
CAS
88847-89-6
分子式
C10H13N5O5
分子量
283.24
MOL 文件
88847-89-6.mol
更新日期
2026/02/25 10:15:33
88847-89-6 結(jié)構(gòu)式
基本信息
中文別名
8-羥基脫氧鳥苷8-OH-脫氧鳥嘌呤
8-羥基-2-脫氧鳥苷
2'-脫氧-8-氧代鳥嘌呤
8-羥基-2'-脫氧鳥嘌呤
2'-脫氧-7,8-二氫-8-氧代鳥苷
英文別名
8-Oxodeoxyguanosine2-Amino-9-((2R,4S,5R)
-3H-purine-6,8(7H,9H)
8-hydroxydeoxyguanosine
8-OXO-2'-DEOXYGUANOSINE
2'-Deoxy-8-oxoguanosine
2'-Deoxy-8-oxo-D-guanosine
8-HYDROXY-2'-DEOXYGUANOSINE
8-oxo-7-hydrodeoxyguanosine
2'-Deoxy-8-hydroxyguanosine
所屬類別
生物化工：脫氧核苷酸及其類似物物理化學(xué)性質(zhì)
熔點(diǎn)217-220°C
密度2.25±0.1 g/cm3(Predicted)
儲(chǔ)存條件2-8°C
溶解度溶于DMSO（高達(dá)10mg/ml）。
酸度系數(shù)(pKa)7.86±0.20(Predicted)
形態(tài)白色至類白色固體
顏色米白色
穩(wěn)定性DMSO中的溶液可在-20°下穩(wěn)定儲(chǔ)存1個(gè)月。
InChIInChI=1S/C10H13N5O5/c11-9-13-7-6(8(18)14-9)12-10(19)15(7)5-1-3(17)4(2-16)20-5/h3-5,16-17H,1-2H2,(H,12,19)(H3,11,13,14,18)/t3-,4+,5+/m0/s1
InChIKeyHCAJQHYUCKICQH-VPENINKCSA-N
SMILESOC[C@H]1O[C@@H](N2C3=C(C(NC(=N3)N)=O)NC2=O)C[C@@H]1O
安全數(shù)據(jù)
警示詞警告
危險(xiǎn)性描述H302-H315-H319-H335
安全說明24/25
WGK Germany3
RTECS號(hào)MF8782675
海關(guān)編碼29349990
存儲(chǔ)類別11 - Combustible Solids
8-OH-脫氧鳥嘌呤價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2026/06/05 | HY-W011540R | 8-OH-脫氧鳥嘌呤 8-Hydroxy-2'-deoxyguanosine (Standard) | 88847-89-6 | 1 mg | 1400元 |
| 2026/06/05 | HY-W011540R | 8-OH-脫氧鳥嘌呤 8-Hydroxy-2'-deoxyguanosine (Standard) | 88847-89-6 | 5 mg | 3504元 |
| 2026/06/05 | HY-W011540R | 8-OH-脫氧鳥嘌呤 8-Hydroxy-2'-deoxyguanosine (Standard) | 88847-89-6 | 10 mg | 5256元 |
常見問題列表
生物活性
8-Hydroxy-2'-deoxyguanosine 是氧化應(yīng)激和致癌反應(yīng)的關(guān)鍵生物標(biāo)志物。靶點(diǎn)
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Human Endogenous Metabolite
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體外研究
8-Hydroxy-2'-deoxyguanosine (8-OHdG) is a good biomarker for risk assessment of various cancers and degenerative diseases. The biomarker 8-Hydroxy-2'-deoxyguanosine (8-OHdG) or 8-oxodG has been a pivotal marker for measuring the effect of endogenous oxidative damage to DNA and as a factor of initiation and promotion of carcinogenesis. The biomarker has been used to estimate the DNA damage in humans after exposure to cancer-causing agents, such as tobacco smoke, asbestos fibers, heavy metals, and polycyclic aromatic hydrocarbons.