89213-87-6
89213-87-6 結(jié)構(gòu)式
基本信息
卡培立肽雜質(zhì)
醋酸卡培立肽
人重組型Α-心房尿鈉肽
醋酸卡培立肽 89213-87-6
α-hANP
Carperitide
ANP HUMAN, 1-28
ANP 1-28, HUMAN
ANF 1-28, HUMAN
ahANF, Carperitide
ANP, ALPHA-, HUMAN
Carperitide Acetate
α-Atriopeptin【human】
物理化學(xué)性質(zhì)
應(yīng)用領(lǐng)域
單雜≤1.0%
醋酸根含量5.0%～12.0%
水分含量≤10.0%
肽含量≥80.0%
常見問題列表
卡培立肽是由三得利株式會社與宮崎醫(yī)科大學(xué)共同研究合成、生產(chǎn)的由28個氨基酸構(gòu)成的α型心房鈉尿肽。
| Target | Value |
|
NPR-A
(Cell-free assay) | 10.8 nM(EC50) |
Carperitide (Atrial Natriuretic Peptide (ANP) (1-28), human, porcine) is a diuretic, natriuretic, and vasodilatory peptide hormone originally isolated from mammalian hearts. In cultured porcine endothelial cells the inhibition by porcine ANP (1-28) of immunoreactive endothelin-1 secretion after stimulation with Angiotensin II (Ang II) is paralleled by an increase in the cellular cGMP level. Porcine ANP (1-28) strongly inhibits immunoreactive endothelin-1 secretion in porcine aorta after stimulation with Ang II. ANP is a cardiac hormone involved in electrolyte and fluid homeostasis. The inhibition by ANP of endothelin-1 secretion stimulated by angiotensin II (ANGII) and thrombin using cultured human umbilical-vein endothelial cells. Human ANP (1-28) inhibits immunoreactive (ir)-endothelin-1 secretion and increases cyclic GMP in the human umbilical-vein endothelial cells. In glomeruli from normal rats, Human 125 I-ANP (1-28) binds to a single population of high affinity receptors with a mean equilibrium dissociation constant of 0.46 nM. Human ANP (1-28) binds to the glomerular ANP receptor with high affinity stimulated cGMP accumulation. Human ANP (1-28) markedly stimulates cGMP generation, but not cAMP generation in normal rat glomeruli.