89283-48-7
89283-48-7 結構式
基本信息
4-chloro-6-MethylpyriMidine-1-thiol
Pyrimidine, 4-chloro-6-(methylthio)-
4-Chloro-6-methylsulfanyl-pyrimidine
4-CHLORO-6-METHYLTHIOPYRIMIDINE ISO 9001：2015 REACH
物理化學性質(zhì)
制備方法
1193-21-1
5188-07-8
89283-48-7
實施例12: 4-氯-6-(甲硫基)嘧啶的合成。在室溫下，將4,6-二氯嘧啶(15.4 g, 0.10 mol)溶解于THF(120 mL)中，隨后加入固體甲硫醇鈉(NaSMe, 8.5 g, 0.12 mol)。將反應混合物加熱至60℃并維持16小時。反應完成后，將混合物冷卻至室溫，用乙酸乙酯(300 mL)和水(300 mL)稀釋。分離有機層，用鹽水洗滌，無水硫酸鈉干燥，濃縮得到橙色油狀物。通過己烷重結晶，得到淺黃色固體產(chǎn)物4-氯-6-(甲硫基)嘧啶(9.85 g, 0.061 mol, 產(chǎn)率61%)。1H NMR (500 MHz, CDCl3) δ: 8.74 (s, 1H), 7.23 (s, 1H), 2.58 (s, 3H)。
參考文獻：
[1] Patent: WO2006/52913, 2006, A1. Location in patent: Page/Page column 236-237
[2] Patent: WO2008/77548, 2008, A1. Location in patent: Page/Page column 46
[3] Patent: WO2009/85913, 2009, A1. Location in patent: Page/Page column 64-65
[4] Bioorganic and Medicinal Chemistry Letters, 2009, vol. 19, # 23, p. 6529 - 6533
[5] Patent: WO2011/45353, 2011, A1. Location in patent: Page/Page column 42-43