89396-94-1
中文名稱
鹽酸咪達普利
英文名稱
(S)-3-[(S)-2-((S)-1-ETHOXYCARBONYL-3-PHENYL-PROPYLAMINO)-PROPIONYL]-1-METHYL-2-OXO-IMIDAZOLIDINE-4-CARBOXYLIC ACID
CAS
89396-94-1
分子式
C20H27N3O6
分子量
405.445
MOL 文件
89396-94-1.mol
更新日期
2026/07/14 13:22:42
89396-94-1 結構式
基本信息
中文別名
咪達普利鹽酸鹽咪達普利及其中間體
(S)-3-((S)-2-(((S)-1-乙氧基-1-氧代-4-苯基丁烷-2-基)氨基)丙酰基)-1-甲基-2-氧代咪唑啉-4-羧酸鹽酸鹽
英文別名
TA 6366Novaloc
SH-6366
Novarok
Tanapril
Tanatril
ACE/TA-6366
IMipadril HCl
Imidaprilhydrochloride
Imidapril HCl (TA-6366)
所屬類別
原料藥：抗高血壓病藥物理化學性質(zhì)
熔點214-216℃
比旋光度D20 -64.1° (c = 0.5 in ethanol)
儲存條件?20°C
溶解度H2O：≥5mg/mL
形態(tài)粉末
顏色白色至棕褐色
旋光度 (Optical Rotation)[α]/D -50 to -70° in ethanol (c=0.5)
水溶解性H2O: ≥5mg/mL
Merck14,4911
鹽酸咪達普利價格(試劑級)
| 報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
| 2026/07/06 | S2109 | 鹽酸咪達普利 Imidapril HCl | 89396-94-1 | 10mg | 569.02元 |
| 2026/06/06 | I0901 | 咪達普利鹽酸鹽 Imidapril Hydrochloride | 89396-94-1 | 25mg | 40元 |
| 2026/06/06 | I0901 | 咪達普利鹽酸鹽 Imidapril Hydrochloride | 89396-94-1 | 100mg | 90元 |
常見問題列表
生物活性
Imidapril HCl是一種血管緊張素轉換酶（ACE）抑制劑，IC50為2.6 nM，用于治療高血壓。靶點
| Target | Value |
| ACE | 2.6 nM |
體外研究
As a prodrug, Imidapril is converted by hydrolysis in the liver into its active form imidaprilat. Imidaprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II and results in vasodilation. Imidaprilat also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow.