899431-18-6
899431-18-6 結(jié)構(gòu)式
基本信息
A-438079
A438079
A 438079
3-[[5-(2,3-Dichlorophenyl)-1H-tetrazol-1-yl]methyl]pyridine monohydrochloride
物理化學(xué)性質(zhì)
安全數(shù)據(jù)
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2026/06/05 | HY-15488AR | A 438079 (hydrochloride) A 438079 hydrochloride (Standard) | 899431-18-6 | 5 mg | 1555元 |
| 2026/06/05 | HY-15488A | A 438079 (hydrochloride) A 438079 hydrochloride | 899431-18-6 | 1 mg | 316元 |
| 2026/06/05 | HY-15488AR | A 438079 (hydrochloride) A 438079 hydrochloride (Standard) | 899431-18-6 | 10 mg | 2333元 |
常見(jiàn)問(wèn)題列表
pIC50: 6.9
In 1321N1 cells stably expressing rat P2X 7 receptors, A 438079 blocks BzATP-(10 μM) evoked changes in intracellular calcium concentrations with an IC 50 of 321 nM. A 438079 is also selective for the P2X 7 receptor, at concentrations up to 100 μM.
A 438079 (80 μmol/kg, i.v.) reduces noxious and innocuous evoked activity of different classes of spinal neurons in neuropathic rats. A 438079 (100 and 300 μmol/kg, i.p.) signi?cantly raises withdrawal thresh-olds in both the SNL and CCI models. Intraperitoneal injection of A 438079 (5 and 15 mg/kg) 60 min after triggering seizures reduces seizure severity and neuronal death within the hippocampus. A 438079 has superior neuroprotective effects compared with an equally dose of phenobarbital (25 mg/kg).?A 438079 partially but signi?cantly prevents the 6-OHDA-induced depletion of striatal DA stores. Pretreatment with A 438079 reduces nociceptive behaviour scores in the HC model.
