92092-36-9
中文名稱
DIPHTHERIA TOXIN
英文名稱
DIPHTHERIA TOXIN
CAS
92092-36-9
基本信息
中文別名
白喉毒素抗體白喉毒素LR單克隆抗體
白喉毒素 來源于白喉桿菌
英文別名
DIPHTHERIA TOXINDiphtheria toxin (CRM197)
DIPHTHERIA TOXIN, CRM MUTANT
CORYNEBACTERIUM DIPHTHERIAE TOXIN
(GLU-52)-DIPHTHERIA TOXIN FROM*CORYNEBAC
(glu52)-diphtheria toxin from*corynebacterium dip
Diphtheria Toxin from Corynebacterium diphtheriae
Diphtheria toxin[Glu-52], Corynebacterium diphtheriae
DIPHTHERIA TOXIN, UNNICKED, CORYNEBACTERIUM DIPHTHERIAE
[glu52]-diphtheria toxin from corynebacterium diphtheriae
安全數據
常見問題列表
生物活性
Diphtheria toxin CRM197 是白喉毒素的一個無毒變種，具有一個單一的突變 (52 位的甘氨酸到谷氨酸的替代)，可以消除其毒性。CRM197 作為載體蛋白廣泛應用于疫苗中。體外研究
Diphtheria toxin CRM197 is an enzymatically inactive and nontoxic form of diphtheria toxin that contains a single amino acid substitution (G52E). Being naturally nontoxic, CRM197 is an ideal carrier protein for conjugate vaccines against encapsulated bacteria and is currently used to vaccinate children globally against Haemophilus influenzae, pneumococcus, and meningococcus.
Diphtheria toxin, a single polypeptide secreted by lysogenic strains of
Corynebacterium diphtheria
, causes the disease diphtheria in humans by gaining entry into the cytoplasm of cells and inhibiting protein synthesis.