941575-71-9

中文名稱 3-(5-BroMo-1-Methyl-1H-indol-3-yl)-4-(benzofuran-3-yl)pyrrole-2,5-dione

英文名稱 3-(5-BroMo-1-Methyl-1H-indol-3-yl)-4-(benzofuran-3-yl)pyrrole-2,5-dione

CAS 941575-71-9

分子式 C21H13BrN2O3

分子量 421.24

MOL 文件 941575-71-9.mol

更新日期 2024/12/13 09:53:00

941575-71-9 結(jié)構(gòu)式

基本信息物理化學(xué)性質(zhì) 安全數(shù)據(jù) 圖譜信息 3-(5-BroMo-1-Methyl-1H-indol-3-yl)-4-(benzofuran-3-yl)pyrrole-2,5-dione價(jià)格(試劑級(jí)) 常見(jiàn)問(wèn)題列表

基本信息

中文別名

3-(苯并呋喃-3-基)-4-(5-溴-1-甲基-1H-吲哚-3-基)-1H-吡咯-2,5-二酮

英文別名

BIP-135
3-(5-BroMo-1-Methyl-1H-indol-3-yl)-4-(benzofuran-3-yl)pyrrole-2,5-dione
3-(Benzofuran-3-yl)-4-(5-bromo-1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione

物理化學(xué)性質(zhì)

沸點(diǎn)643.5±55.0 °C(Predicted)

密度1?+-.0.1 g/cm3(Predicted)

儲(chǔ)存條件room temp

溶解度在DMSO中的溶解度≥15mg/mL

酸度系數(shù)(pKa)7.44±0.60(Predicted)

形態(tài)粉末

顏色淺橙色至深橙色

安全數(shù)據(jù)

危險(xiǎn)性符號(hào)(GHS) 有毒 (GHS06)

GHS06

警示詞危險(xiǎn)

危險(xiǎn)性描述H301

防范說(shuō)明P301+P310

危險(xiǎn)品標(biāo)志T

危險(xiǎn)類別碼25

安全說(shuō)明45

危險(xiǎn)品運(yùn)輸編號(hào)UN 2811 6.1 / PGIII

WGK Germany3

圖譜信息

3-(5-BroMo-1-Methyl-1H-indol-3-yl)-4-(benzofuran-3-yl)pyrrole-2,5-dione(941575-71-9)核磁圖(¹HNMR)

3-(5-BroMo-1-Methyl-1H-indol-3-yl)-4-(benzofuran-3-yl)pyrrole-2,5-dione價(jià)格(試劑級(jí))

報(bào)價(jià)日期	產(chǎn)品編號(hào)	產(chǎn)品名稱	CAS號(hào)	包裝	價(jià)格
2026/06/05	HY-111055	3-(5-BroMo-1-Methyl-1H-indol-3-yl)-4-(benzofuran-3-yl)pyrrole-2,5-dione BIP-135	941575-71-9	1mg	395元
2026/06/05	HY-111055	3-(5-BroMo-1-Methyl-1H-indol-3-yl)-4-(benzofuran-3-yl)pyrrole-2,5-dione BIP-135	941575-71-9	5mg	915元
2026/06/05	HY-111055	BIP-135	941575-71-9	10 mM * 1 mLin DMSO	1006元

常見(jiàn)問(wèn)題列表

生物活性

BIP-135 是一個(gè)高效、選擇性的，ATP 競(jìng)爭(zhēng)性的 GSK-3 抑制劑，對(duì) GSK-3α 和 GSK-3β 作用的IC50 值分別為 16 nM 和 21 nM。BIP 135 具有神經(jīng)保護(hù)作用。

靶點(diǎn)

GSK-3α

16 nM (IC ₅₀ )

GSK-3β

21 nM (IC ₅₀ )

體外研究

BIP-135 (20-30 μM; 72 hours) increases the survival motor neuron (SMN) protein levels at a dose of 25 μM in human SMA fibroblasts. And the typical bell-shaped dose-response curve is observed due to some toxicity at higher concentrations.
BIP-135 (20 μM; 48 hours) is a superior neuroprotective agent in the model of oxidative stress.

Western Blot Analysis

Cell Line:	Human SMA fibroblasts
Concentration:	20 μM, 25 μM, 30 μM
Incubation Time:	72 hours
Result:	Led to a 7-fold increase in SMN levels at 25 μM.

體內(nèi)研究

BIP-135 does not appear to be toxic and was well-tolerated by the animals (no decrease in body weight).
BIP-135 (75 mg/kg; i.p.; daily; from postnatal day 0 to 21) prolongs the median survival time of Δ7 SMA KO mouse model of spinal muscular atrophy.

Animal Model:	Male and female SMN2 ^+/+ , SMN2Δ7 ^+/+ , Smn ^+/– mice
Dosage:	75 mg/kg
Administration:	Intraperitoneal injection; daily; from postnatal day 0 to 21
Result:	Caused a modest extension in the median survival of SMA KO animals by two days.