943994-02-3
943994-02-3 結(jié)構(gòu)式
基本信息
2H-苯并[B][1,4]噁嗪-3(4H)-酮-6-硼酸嚬哪醇酯
3-氧代-2H,4H-苯并[B][1,4]惡嗪-6-硼酸頻哪醇酯
3-羰基-3,4-二氫-2H-1,4-苯并惡嗪-6-硼酸頻哪醇酯
3-氧代-3,4-二氫-2H-苯并[B][1,4]噁嗪-6-硼酸頻哪醇酯
6-(4,4,5,5-四甲基-1,3,2-二氧硼烷-2-基)-2H-1,4-苯并噁嗪-3(4H)-酮
3-Oxo-2H,4H-benzo[b][1,4]oxazine-6-boronic acid pinacol ester
6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4H-1,4-benzo...
3-Oxo-3,4-dihydro-2H-1,4-benzoxazine-6-boronic acid pinacol ester
3-Oxo-3,4-dihydro-2H-benzo[b][1,4]oxazine-6-boronic Acid Pinacol Ester
6-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-4H-1,4-benzoxazin-3-one
6-(4,4,5,5-tetraMethyl-1-3,2-dioxaborolan-2-yl)-2H-1,4-benzoxazin-3(4H)-one
6-(tetraMethyl-1,3,2-dioxaborolan-2-yl)-3,4- dihydro-2H-1,4-benzoxazin-3-one
2H-1,4-Benzoxazin-3(4H)-one,6-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-
6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2H-benzo[b][1,4]oxazin-3(4H)-one
物理化學(xué)性質(zhì)
制備方法
24036-52-0
73183-34-3
943994-02-3
以6-溴-2H-1,4-苯并噁嗪-3(4H)-酮（2.3g，10mmol）和聯(lián)硼酸頻那醇酯（3.05g，12mmol）為原料，在二惡烷（20mL）中溶解后，依次加入乙酸鉀（2g，20mmol）和Pd(dppf)Cl2（730mg，1mmol）。反應(yīng)體系經(jīng)氮?dú)獯祾吆?，?0℃下攪拌反應(yīng)過(guò)夜。反應(yīng)完成后，將混合物用乙酸乙酯（200mL）稀釋并過(guò)濾。有機(jī)相依次用鹽水洗滌，無(wú)水硫酸鈉干燥，減壓濃縮得到粗產(chǎn)物。粗產(chǎn)物通過(guò)硅膠柱色譜（洗脫劑：石油醚/乙酸乙酯=3:1）純化，得到3-氧代-2H,4H-苯并[b][1,4]噁嗪-6-硼酸頻哪醇酯（1.9g，收率69%）。
參考文獻(xiàn)：
[1] Patent: WO2015/153683, 2015, A1. Location in patent: Paragraph 0937
[2] Patent: WO2017/211303, 2017, A1. Location in patent: Page/Page column 36
[3] Patent: WO2010/116282, 2010, A1. Location in patent: Page/Page column 55-56
[4] Patent: WO2007/77961, 2007, A2. Location in patent: Page/Page column 227
[5] Patent: KR2016/37198, 2016, A. Location in patent: Paragraph 3281-3283
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱(chēng) | CAS號(hào) | 包裝 | 價(jià)格 |
| 2026/06/05 | XW0294399402302 | 3-氧代-2H,4H-苯并[B][1,4]噁嗪-6-硼酸頻哪醇酯 | 943994-02-3 | 250MG | 150元 |
| 2026/06/05 | XW0294399402301 | 3-氧代-2H,4H-苯并[B][1,4]噁嗪-6-硼酸頻哪醇酯 | 943994-02-3 | 100MG | 86元 |
| 2024/04/30 | H62168 | 3-羰基-3,4-二氫-2H-1,4-苯并惡嗪-6-硼酸頻哪醇酯 3-Oxo-3,4-dihydro-2H-1,4-benzoxazine-6-boronic acid pinacol ester | 943994-02-3 | 250mg | 1481元 |