96478-43-2
96478-43-2 結(jié)構(gòu)式
基本信息
中文別名
茚達酮 英文別名
IrindaloneLu 21-?098
1-[2-[4-[(1R)-3β-(4-Fluorophenyl)-2,3-dihydro-1H-inden-1α-yl]-1-piperazinyl]ethyl]-2-imidazolidinone
2-Imidazolidinone, 1-[2-[4-[(1R,3S)-3-(4-fluorophenyl)-2,3-dihydro-1H-inden-1-yl]-1-piperazinyl]ethyl]-
常見問題列表
生物活性
Irindalone 是一種 5-羥色胺 (5-HT2) 拮抗劑。靶點
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5-HT 2 Receptor
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體外研究
Irindalone causes a concentration-related inhibition of serotonin-induced contractions and shifts the serotonin curve to the right. Irindalone is more potent in inhibiting the serotonin-induced contractions. Irindalone has a similar profile in vitro, with a high affinity for serotonin 5-HT 2 receptors and about a 10 times lower affinity for α 1 -adrenoceptors.
體內(nèi)研究
Irindalone dose dependently lowers the blood pressure in spontaneously hypertensive rats (SHR) and renal hypertensive dogs.