98072-47-0
基本信息
溶血素 O
鏈球菌溶素O
鏈球菌溶血素O
溶血素O抗原SLO
化合物 T19565
ATCC 15300 鏈球菌
來自化膿性鏈球菌的鏈球菌溶血素O
鏈球菌溶血素O 來源于化膿鏈球菌
Einecs 308-500-3
Streptococcus sp.
STREPTOLYSIN O REAGENT
STREPTOLYSIN O GAMMA-IRRADIATED
Hemolysins O, Streptococcus group A
STREPTOLYSIN O FROM STREPTOCOCCUS*PYOGEN ES
Native Streptococcus pyogenes Streptolysin O
物理化學(xué)性質(zhì)
安全數(shù)據(jù)
very toxic hazardous materials
Acute Tox. 2 Inhalation
Acute Tox. 2 Oral
Aquatic Chronic 2
Eye Dam. 1
Skin Irrit. 2
常見問題列表
Streptolysin O is a labile toxin, and, with time, activity is irreversibly lost. The rate of activity loss is slowed by incubation with 0.1 M 2-mercaptoethanol or 0.01 M ethylenediaminetetraacetic acid (EDTA).
Streptolysin O, belongs to the group of thiol-activated toxins, is a secreted virulence factor of GAS that induces apoptosis in neutrophils and macrophages at later time points (~4 h). Streptolysin O induces eukaryotic cell lysis in a cholesterol-dependent manner, is highly upregulated in the GAS M1T1 clone during bloodstream dissemination. Streptolysin O is known to promote Group A Streptococcus (GAS) resistance to phagocytic clearance by neutrophils, a critical first element of host defense against invasive bacterial infection.