98948-95-9
98948-95-9 結(jié)構(gòu)式
基本信息
4-羥基-6-溴喹啉-3-羧酸
6-溴-4-羥基喹啉-3-甲酸
BUTTPARK 21\09-50
OTAVA-BB BB7110950773
6-BROMO-4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID
6-bromo-4-hydroxy-3-quinolinecarboxylic acid
4-Hydroxy-6-broMoquinoline-3-carboxylic acid
3-Quinolinecarboxylic acid, 6-bromo-4-hydroxy-
6-BROMO-4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID CAS:98948-95-9
物理化學(xué)性質(zhì)
制備方法
122794-99-4
98948-95-9
以6-溴-4-羥基-3-喹啉羧酸乙酯為原料合成4-羥基-6-溴喹啉-3-羧酸的一般步驟如下：將6-溴-4-羥基-3-喹啉羧酸乙酯（102.59 g，337.7 mmol）懸浮于10%氫氧化鉀水溶液（689 mL）中，加熱回流5小時，反應(yīng)液變?yōu)闇\棕色。反應(yīng)完成后，冷卻至室溫，過濾去除未溶解的固體顆粒。濾液用二氯甲烷萃取，以除去中性雜質(zhì)。水層用3.0 N鹽酸中和，析出白色沉淀。過濾收集固體，用水洗滌?？諝庵懈稍锖?，得到4-羥基-6-溴喹啉-3-羧酸91 g（收率98%），為白色固體。EI-HRMS m/e計(jì)算值C10H6BrNO3（M+）266.9531，實(shí)測值266.9521。
參考文獻(xiàn)：
[1] Patent: US2006/63805, 2006, A1. Location in patent: Page/Page column 9
[2] ChemMedChem, 2015, vol. 10, # 5, p. 836 - 849
[3] Patent: CN106432073, 2017, A. Location in patent: Paragraph 0061; 0062; 0067; 0068
[4] European Journal of Medicinal Chemistry, 2015, vol. 99, p. 36 - 50
[5] Chemistry of Heterocyclic Compounds (New York, NY, United States), 1995, vol. 31, # 2, p. 167 - 175