5-異喹啉硼酸性質(zhì)、用途與生產(chǎn)工藝

用途

生產(chǎn)方法 

34784-04-8

371766-08-4

在-78℃下，向根據(jù)文獻(xiàn)方法（Brown, W. D等人，Synthesis 2002, 83）制備的5-溴異喹啉（1.46 g，7.0 mmol）的THF（20 mL）溶液中，依次加入硼酸三異丙酯（2.4 mL，10.5 mmol）和叔丁基鋰（1.7 M，9.5 mL）。反應(yīng)混合物緩慢升溫至室溫并攪拌過夜。反應(yīng)完成后，用1N HCl（10 mL）淬滅反應(yīng)，傾析THF層后得到固體產(chǎn)物。經(jīng)鑒定，該固體為5-異喹啉硼酸（1.0 g，收率82%）。質(zhì)譜（ESI）顯示（M + 1）峰為174.12。

參考文獻(xiàn)：

[1] Patent: WO2005/72732, 2005, A1. Location in patent: Page/Page column 61

[2] Patent: WO2008/6480, 2008, A1. Location in patent: Page/Page column 5-6

5-異喹啉硼酸 上下游產(chǎn)品信息

上游原料

下游產(chǎn)品

5-異喹啉硼酸 生產(chǎn)廠家

5-異喹啉硼酸 圖譜信息:

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