甲磺酸氟馬替尼
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- CAS號:
- 895519-91-2
- 英文名:
- Flumatinib mesylate
- 英文別名:
- CS-1023;HHGV678 mesylate;FluMatinib Mesylate;Flumatinib mesylate (HHGV-678);Flumatinib mesylate, 10 mM in DMSO;N-(6-Methyl-5-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)pyridin-3-yl)-4-((4-methylpiperazin-1-yl);N-(6-Methyl-5-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)pyridin-3-yl)-4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)benzamide methanesulfonate;methanesulfonic acid,4-[(4-methylpiperazin-1-yl)methyl]-N-[6-methyl-5-[(4-pyridin-3-ylpyrimidin-2-yl)amino]pyridin-3-yl]-3-(trifluoromethyl)benzamide;HHGV-678,PDGFRβ,HHGV678,c-Abl,Bcr-Abl,Platelet-derived growth factor receptor,PDGFR,HHGV 678,SCFR,Flumatinib mesylate,c-Kit,Flumatinib,CD117,Inhibitor,inhibit;BenzaMide, 4-[(4-Methyl-1-piperazinyl)Methyl]-N-[6-Methyl-5-[[4-(3-pyridinyl)-2-pyriMidinyl]aMino]-3-pyridinyl]-3-(trifluoroMethyl)-, MonoMethanesulfonate (9CI)
- 中文名:
- 甲磺酸氟馬替尼
- 中文別名:
- 甲磺酸氟馬替尼;甲磺酸氟馬替尼/氟馬替尼;甲磺酸氟馬替尼,10 MM DMSO 溶液;FLUMATINIB (HH-GV-678)甲磺酸鹽;多種激酶抑制劑(FLUMATINIB MESYLATE);N-(6-甲基-5-((4-(吡啶-3-基)嘧啶-2-基)氨基)吡啶-3-基)-4-((4-甲基哌嗪-1-基)甲基)-3-(三氟甲基)苯甲酰胺甲磺酸鹽
- CBNumber:
- CB12667200
- 分子式:
- C30H33F3N8O4S
- 分子量:
- 658.6944296
- MOL File:
- 895519-91-2.mol
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甲磺酸氟馬替尼化學(xué)性質(zhì)
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儲存條件:
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Store at -20°C
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溶解度:
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H2O : 50 mg/mL (75.91 mM; Need ultrasonic)DMSO : 50 mg/mL (75.91 mM; Need ultrasonic)
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形態(tài):
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Powder
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顏色:
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Light brown to yellow
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甲磺酸氟馬替尼性質(zhì)、用途與生產(chǎn)工藝
甲磺酸氟馬替尼，用于治療費(fèi)城染色體陽性的慢性髓性白血?。≒h+CML），由國內(nèi)江蘇豪森藥業(yè)股份有限公司開發(fā)，2007年9月批準(zhǔn)臨床，2019年獲得中國國家藥品監(jiān)督管理局（CNMPA）批準(zhǔn)，用于治療費(fèi)城染色體陽性的慢性髓性白血病慢性期（CML-CP）。氟馬替尼的結(jié)構(gòu)與伊馬替尼類似，但中心苯環(huán)被修改為吡啶，并在苯酰胺基團(tuán)上添加了CF3基團(tuán)。這些改變使得氟馬替尼在III期臨床試驗(yàn)中顯示出比伊馬替尼更高的療效和相似的安全性。
甲磺酸氟馬替尼合成路線
甲磺酸氟馬替尼
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS編號 | 包裝 | 價(jià)格 |
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| 2026/06/05 | HY-13905 | 甲磺酸氟馬替尼/氟馬替尼
Flumatinib mesylate | 895519-91-2 | 1 mg | 400元 |
| 2026/06/05 | HY-13905 | 甲磺酸氟馬替尼/氟馬替尼
Flumatinib mesylate | 895519-91-2 | 5 mg | 1000元 |
895519-91-2, 甲磺酸氟馬替尼 相關(guān)搜索:
- 抑制劑
- 雜質(zhì)對照品
- 標(biāo)準(zhǔn)品
- 有機(jī)光電
- 細(xì)胞生物學(xué)試劑
- 原料藥標(biāo)樣
- C30H33F3N8O4S
- C29H29F3N8OCH4O3S
- 多種激酶抑制劑(FLUMATINIB MESYLATE)
- 甲磺酸氟馬替尼,10 MM DMSO 溶液
- N-(6-甲基-5-((4-(吡啶-3-基)嘧啶-2-基)氨基)吡啶-3-基)-4-((4-甲基哌嗪-1-基)甲基)-3-(三氟甲基)苯甲酰胺甲磺酸鹽
- FLUMATINIB (HH-GV-678)甲磺酸鹽
- 甲磺酸氟馬替尼/氟馬替尼
- 甲磺酸氟馬替尼
- 895519-91-2
- Flumatinib mesylate, 10 mM in DMSO
- HHGV-678,PDGFRβ,HHGV678,c-Abl,Bcr-Abl,Platelet-derived growth factor receptor,PDGFR,HHGV 678,SCFR,Flumatinib mesylate,c-Kit,Flumatinib,CD117,Inhibitor,inhibit
- N-(6-Methyl-5-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)pyridin-3-yl)-4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)benzamide methanesulfonate
- Flumatinib mesylate (HHGV-678)
- HHGV678 mesylate
- CS-1023
- methanesulfonic acid,4-[(4-methylpiperazin-1-yl)methyl]-N-[6-methyl-5-[(4-pyridin-3-ylpyrimidin-2-yl)amino]pyridin-3-yl]-3-(trifluoromethyl)benzamide
- N-(6-Methyl-5-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)pyridin-3-yl)-4-((4-methylpiperazin-1-yl)
- BenzaMide, 4-[(4-Methyl-1-piperazinyl)Methyl]-N-[6-Methyl-5-[[4-(3-pyridinyl)-2-pyriMidinyl]aMino]-3-pyridinyl]-3-(trifluoroMethyl)-, MonoMethanesulfonate (9CI)/FluMatinib Mesylate
- FluMatinib Mesylate
- BenzaMide, 4-[(4-Methyl-1-piperazinyl)Methyl]-N-[6-Methyl-5-[[4-(3-pyridinyl)-2-pyriMidinyl]aMino]-3-pyridinyl]-3-(trifluoroMethyl)-, MonoMethanesulfonate (9CI)