洛度沙胺
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- CAS號:
- 53882-12-5
- 英文名:
- Lodoxamide
- 英文別名:
- Lodoxamida;Lodoxamidum;Unii-spu695od73;Lodoxamide (U42585E);LODOXAMIDE USP/EP/BP;Lodoxamide lmpurity 16;Lodoxamide lmpurity 01;Lodoxamidum [inn-latin];Lodoxamida [inn-spanish];Lodoxamide, 10 mM in DMSO
- 中文名:
- 洛度沙胺
- 中文別名:
- 洛度沙胺;羅多沙胺;羅多沙胺;洛草氨酸;洛度沙胺雜質(zhì)01;洛草氨酸 Lodoxamide;洛草氨酸 Lodoxamide;洛草氨酸,10 MM DMSO 溶液;2,2'-((2-氯-5-氰基-1,3-亞苯基)雙(氮雜二基))雙(2-氧代乙酸);2,2'-((2-氯-5-氰基-1,3-亞苯基)雙(氮雜二基))雙(2-氧代乙酸)
- CBNumber:
- CB21179062
- 分子式:
- C11H6ClN3O6
- 分子量:
- 311.63
- MOL File:
- 53882-12-5.mol
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洛度沙胺化學性質(zhì)
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熔點:
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212° (dec)
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密度:
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1.78±0.1 g/cm3(Predicted)
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儲存條件:
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Store at -20°C
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溶解度:
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DMF: 3 mg/ml; DMSO: 5 mg/ml; PBS (pH 7.2): 2 mg/mL
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酸度系數(shù)(pKa):
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2.07±0.50(Predicted)
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形態(tài):
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A solid
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顏色:
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Off-white to pink
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穩(wěn)定性:
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Hygroscopic
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InChI:
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1S/C11H6ClN3O6/c12-7-5(14-8(16)10(18)19)1-4(3-13)2-6(7)15-9(17)11(20)21/h1-2H,(H,14,16)(H,15,17)(H,18,19)(H,20,21)
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InChIKey:
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RVGLGHVJXCETIO-UHFFFAOYSA-N
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SMILES:
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Clc1c(cc(cc1NC(=O)C(=O)O)C#N)NC(=O)C(=O)O
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洛度沙胺性質(zhì)、用途與生產(chǎn)工藝
Lodoxamide (U-42585E free acid) 是作為肥大細胞穩(wěn)定劑的抗過敏化合物, 用于研究哮喘和過敏性結膜炎。
Lodoxamide inhibits compound 48/80-induced histamine release and ionophore-induced
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Ca influx with associated histamine release in purified rat peritoneal mast cells. The chemotactic response of eosinophils to fMLP as well as to IL-5 is significant and dose-dependent inhibited by Lodoxamide. Lodoxamide is also able to strongly inhibit the release of eosinophil peroxidase after IgA-dependent activation and, to a lesser extent, the release of eosinophil cationic protein and eosinophil-derived neurotoxin.
Lodoxamide has been demonstrated to have cromolyn-like activity when studied in the rat peritoneal mast cell assay (PCA) model3 and in Ascaris antigen-sensitized rhesus monkeys. When given intravenously, orally, or intrabronchially by aerosol, lodoxamide significantly inhibits the increased respiratory frequency and decreased tidal volume induced by antigen challenge in Ascaris-sensitized. anesthetized rhesus monkeys. Addition of lodoxamide tromethamine to Euro-Collins or University of Wisconsin solution results in a marked decrease in lung reperfusion injury as demonstrated by increased oxygenation, decreased microvascular permeability, and increased compliance. Patients treated with lodoxamide tromethamine demonstrate an improvement in daytime breathing difficulty, cough, sputum production, and sleep.
洛度沙胺
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS編號 | 包裝 | 價格 |
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| 2026/06/05 | HY-14270R | 洛度沙胺
Lodoxamide (Standard) | 53882-12-5 | 5 mg | 1500元 |
| 2026/06/05 | HY-14270R | 洛度沙胺
Lodoxamide (Standard) | 53882-12-5 | 10 mg | 2250元 |
53882-12-5, 洛度沙胺 相關搜索:
- 配體家族
- 雜質(zhì)對照品
- 抑制劑
- C11H6ClN3O6
- 洛度沙胺
- 洛草氨酸 Lodoxamide
- 羅多沙胺
- 羅多沙胺
- 洛草氨酸 Lodoxamide
- 2,2'-((2-氯-5-氰基-1,3-亞苯基)雙(氮雜二基))雙(2-氧代乙酸)
- 洛草氨酸,10 MM DMSO 溶液
- 洛度沙胺雜質(zhì)01
- 2,2'-((2-氯-5-氰基-1,3-亞苯基)雙(氮雜二基))雙(2-氧代乙酸)
- 洛草氨酸
- 53882-12-5
- Lodoxamide lmpurity 01
- Lodoxamide, 10 mM in DMSO
- Lodoxamide lmpurity 16
- Inhibitor,Lodoxamide,inhibit,U-42585E,Histamine Receptor
- 2,2-((2-chloro-5-cyano-1,3-phenylene)bis(azanediyl))bis(2-oxoacetic acid)(WXC06973)
- LODOXAMIDE USP/EP/BP
- Lodoxamide (U42585E)
- 2-[2-chloro-5-cyano-3-(oxaloamino)anilino]-2-oxoacetic acid
- 2,2'-((2-chloro-5-cyano-1,3-phenylene)bis(azanediyl))bis(2-oxoacetic acid)
- Unii-spu695od73
- N,N'-(2-Chlor-5-cyan-3-phenylen)dioxamsaeure
- Lodoxamidum [inn-latin]
- Lodoxamidum
- Lodoxamida [inn-spanish]
- Lodoxamida
- Acetic acid, 2,2'-((2-chloro-5-cyano-1,3-phenylene)diimino)bis(2-oxo-
- 2,2'-[(2-Chloro-5-cyano-1,3-phenylene)diimino]bis[2-oxoacetic acid]