洛度沙胺
| 中文名稱 | 洛度沙胺 |
|---|---|
| 中文同義詞 | 洛草氨酸;2,2'-((2-氯-5-氰基-1,3-亞苯基)雙(氮雜二基))雙(2-氧代乙酸);洛度沙胺雜質01;洛草氨酸,10 MM DMSO 溶液;2,2'-((2-氯-5-氰基-1,3-亞苯基)雙(氮雜二基))雙(2-氧代乙酸);洛草氨酸 Lodoxamide;羅多沙胺;羅多沙胺 |
| 英文名稱 | Lodoxamide |
| 英文同義詞 | 2,2'-[(2-Chloro-5-cyano-1,3-phenylene)diimino]bis[2-oxoacetic acid];Acetic acid, 2,2'-((2-chloro-5-cyano-1,3-phenylene)diimino)bis(2-oxo-;Lodoxamida;Lodoxamida [inn-spanish];Lodoxamidum;Lodoxamidum [inn-latin];N,N'-(2-Chlor-5-cyan-3-phenylen)dioxamsaeure;Unii-spu695od73 |
| CAS號 | 53882-12-5 |
| 分子式 | C11H6ClN3O6 |
| 分子量 | 311.63 |
| EINECS號 | |
| 相關類別 | |
| Mol文件 | 53882-12-5.mol |
| 結構式 | ![]() |
洛度沙胺 性質
| 熔點 | 212° (dec) |
|---|---|
| 密度 | 1.78±0.1 g/cm3(Predicted) |
| 儲存條件 | Store at -20°C |
| 溶解度 | DMF:3mg/mL; DMSO:5mg/mL; PBS(pH 7.2):2 mg/mL |
| 形態(tài) | 固體 |
| 酸度系數(pKa) | 2.07±0.50(Predicted) |
| 顏色 | 米白色至粉紅色 |
| 穩(wěn)定性 | 吸濕性 |
| InChI | 1S/C11H6ClN3O6/c12-7-5(14-8(16)10(18)19)1-4(3-13)2-6(7)15-9(17)11(20)21/h1-2H,(H,14,16)(H,15,17)(H,18,19)(H,20,21) |
| InChIKey | RVGLGHVJXCETIO-UHFFFAOYSA-N |
| SMILES | Clc1c(cc(cc1NC(=O)C(=O)O)C#N)NC(=O)C(=O)O |
Lodoxamide inhibits compound 48/80-induced histamine release and ionophore-induced 45 Ca influx with associated histamine release in purified rat peritoneal mast cells. The chemotactic response of eosinophils to fMLP as well as to IL-5 is significant and dose-dependent inhibited by Lodoxamide. Lodoxamide is also able to strongly inhibit the release of eosinophil peroxidase after IgA-dependent activation and, to a lesser extent, the release of eosinophil cationic protein and eosinophil-derived neurotoxin.
Lodoxamide has been demonstrated to have cromolyn-like activity when studied in the rat peritoneal mast cell assay (PCA) model3 and in Ascaris antigen-sensitized rhesus monkeys. When given intravenously, orally, or intrabronchially by aerosol, lodoxamide significantly inhibits the increased respiratory frequency and decreased tidal volume induced by antigen challenge in Ascaris-sensitized. anesthetized rhesus monkeys. Addition of lodoxamide tromethamine to Euro-Collins or University of Wisconsin solution results in a marked decrease in lung reperfusion injury as demonstrated by increased oxygenation, decreased microvascular permeability, and increased compliance. Patients treated with lodoxamide tromethamine demonstrate an improvement in daytime breathing difficulty, cough, sputum production, and sleep.
安全信息
| WGK Germany | WGK 3 |
|---|---|
| 存儲類別 | 11 - 可燃固體 |
| 更新日期 | 產品編號 | 產品名稱 | CAS號 | 包裝 | 價格 |
|---|---|---|---|---|---|
| 2026/06/05 | HY-14270R | 洛度沙胺 Lodoxamide (Standard) | 53882-12-5 | 5 mg | 1500元 |
| 2026/06/05 | HY-14270R | 洛度沙胺 Lodoxamide (Standard) | 53882-12-5 | 10 mg | 2250元 |
