Ro 64-6198
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- CAS號:
- 280783-56-4
- 英文名:
- Ro 64-6198
- 英文別名:
- Ro 64-6198;Ro 64-6198 >=98% (HPLC);1,3,8-Triazaspiro[4.5]decan-4-one, 8-[(1S,3aS)-2,3,3a,4,5,6-hexahydro-1H-phenalen-1-yl]-1-phenyl-
- 中文名:
- Ro 64-6198
- 中文別名:
- 化合物 T16772;Ro 64-6198試劑;Ro 64-6198試劑;化合物 Ro 64-6198;化合物:Ro 64-6198 CAS:280783-56-4;化合物:Ro 64-6198 CAS:280783-56-4
- CBNumber:
- CB21386123
- 分子式:
- C26H31N3O
- 分子量:
- 401.54
- MOL File:
- 280783-56-4.mol
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Ro 64-6198化學(xué)性質(zhì)
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沸點(diǎn):
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626.2±55.0 °C(Predicted)
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密度:
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1.25±0.1 g/cm3(Predicted)
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儲存條件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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酸度系數(shù)(pKa):
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15.03±0.20(Predicted)
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形態(tài):
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Solid
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顏色:
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White to yellow
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InChIKey:
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JLFMYEAXZNPWBK-REWPJTCUSA-N
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SMILES:
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O=C1C2(CCN([C@]3([H])C4=CC=CC5=C4[C@](CCC5)([H])CC3)CC2)N(C6=CC=CC=C6)CN1
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Ro 64-6198性質(zhì)、用途與生產(chǎn)工藝
Ro 64-6198 是一種有效的,選擇性的,非肽,高親和力,高細(xì)胞通透性和腦滲透 N/OFQ 受體 (NOP) 激動(dòng)劑,EC50 值為 25.6 nM。Ro 64-6198 對 NOP 受體的選擇性至少是經(jīng)典阿片受體的 100 倍。Ro 64-6198 可用于壓力和焦慮,成癮,神經(jīng)性疼痛,咳嗽和厭食癥的研究。
Ro 64-6198 also produces rapid desensitization of the NOP receptor. In vitro studies shows that treatment with Ro 64-6198 results in a functional desensitization of the receptor, a loss in binding sites, and an apparent decrease in binding affinity. The desensitization produced by Ro 64-6198 is not reversed by acidic washes.
Ro 64-6198 does recruit both arrestin3 (
EC
50
of 0.912 μM) and arrestin2 (
EC
50
of 1.20 μM) to the NOP receptor in a concentration-dependent manner comparably with N/OFQ.
At low doses Ro 64-6198 is anxiolytic in several neophobic tests, including the marble burying test in mice, the elevated plus maze in rats and the open field test in rats. In the marble burying test, at 1 mg/kg, i.p., Ro 64-6198 produces a decrease in the number of marbles buried, without altering locomotor activity, indicating a decrease in neophobia and anxiety. Ro 64-6198 selectively increases the number of open arm transitions and time spent in the open arms of the elevated plus maze at doses of 0.32-3 mg/kg, i.p., without affecting closed arm transitions or locomotor activity in the closed arms. In the open field test, Ro 64-6198, at doses of 0.32-3 mg/kg, attenuates the inhibition of exploration that results from the stress of a novel environment.
Ro 64-6198
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS編號 | 包裝 | 價(jià)格 |
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| 2026/06/05 | HY-12844 | Ro 64-6198 Ro 64-6198 | 280783-56-4 | 1mg | 900元 |
| 2026/06/05 | HY-12844 | Ro 64-6198 Ro 64-6198 | 280783-56-4 | 5mg | 2160元 |
280783-56-4, Ro 64-6198 相關(guān)搜索:
- 抑制劑
- 化合物 Ro 64-6198
- 化合物:Ro 64-6198 CAS:280783-56-4
- Ro 64-6198試劑
- 化合物:Ro 64-6198 CAS:280783-56-4
- Ro 64-6198試劑
- 化合物 T16772
- 280783-56-4
- 1,3,8-Triazaspiro[4.5]decan-4-one, 8-[(1S,3aS)-2,3,3a,4,5,6-hexahydro-1H-phenalen-1-yl]-1-phenyl-
- Ro 64-6198 >=98% (HPLC)
- Ro 64-6198