SCR7性質(zhì)、用途與生產(chǎn)工藝

生物活性

SCR7 是一種特異性 DNA Ligase IV 抑制劑，其阻斷非同源性末端連接(NHEJ)。

體外研究

SCR7 effectively inhibits the formation of multimers at 200 μM and above. SCR7 successfully inhibits cell proliferation of MCF7, A549, HeLa, T47D, A2780, HT1080, and Nalm6 with IC50 of 40, 34, 44, 8.5, 120, 10, and 50 μM, respectively. SCR7 suppresses the NHEJ repair of CRISPR-Cas9-induced DSBs.

體內(nèi)研究

SCR7 treatment (10 mg/kg, i.m.) signi?cantly reduces breast adenocarcinoma-induced tumor, and exhibits 4-fold increase in lifespan compared with control group. However, in Swiss albino mice with Dalton’s lymphoma tumor model, SCR7 (20 mg/kg, i.p.) exhibits neither tumor regression nor increase in lifespan. In BALB/c mice, SCR7 (20 mg/kg, i.p.) signi?cantly enhances the cytotoxic effects of radiation, etoposide and 3-Aminobenzamide on tumor derived from Dalton’s lymphoma (DLA) cells.

SCR7 上下游產(chǎn)品信息

上游原料

下游產(chǎn)品

SCR7 試劑級價格

更新日期	產(chǎn)品編號	產(chǎn)品名稱	CAS編號	包裝	價格
2025/12/22	HY-12742	SCR7 SCR7	1533426-72-0	1 mg	784元
2025/12/22	HY-12742	SCR7 SCR7	1533426-72-0	5mg	2048元

SCR7 生產(chǎn)廠家

 

SCR7 圖譜信息:

1533426-72-0, SCR7 相關(guān)搜索:

• Inhibitors
• 標(biāo)準(zhǔn)品
• 小分子抑制劑
• 抑制劑
• 小分子抑制劑，天然產(chǎn)物
• SCR7 (SCR-7)
• 2,3-二氫-5,6-二[(E)-(苯基亞甲基)氨基]-2-硫代-4(1H)-嘧啶酮
• 1533426-72-0
• SCR7 (SCR-7)
• 5,6-bis[(E)-(phenylmethylidene)amino]-2-sulfanylidene-1,2,3,4-tetrahydropyrimidin-4-one
• CS-1733
• 4(1H)-Pyrimidinone, 2,3-dihydro-5,6-bis[(E)-(phenylmethylene)amino]-2-thioxo-
• SCR7 USP/EP/BP
• SCR7
• 5,6-bis((E)-benzylideneamino)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one
• 5,6-bis((E)-benzylideneamino)-2-mercaptopyrimidin-4-ol
• 2,3-Dihydro-5,6-bis[(E)-(phenylmethylene)amino]-2-thioxo-4(1H)-pyrimidinone