5-溴-6-氮尿嘧啶性質(zhì)、用途與生產(chǎn)工藝

用途

5-溴-6-氮尿嘧啶主要用作醫(yī)藥中間體。

生產(chǎn)方法 

461-89-2

4956-05-2

1) 6-溴-1,2,4-三嗪-3,5(2H,4H)-二酮（2i）的合成：將1,2,4-三嗪-3,5(2H,4H)-二酮（50 g，442 mmol）溶于800 mL水中，加入60 mL溴，于60℃反應(yīng)10小時(shí)。反應(yīng)完成后，將反應(yīng)液緩慢加入氨水溶液中調(diào)節(jié)至pH=5。隨后用乙酸乙酯萃取，有機(jī)相用無(wú)水硫酸鎂干燥。過(guò)濾后，濃縮至干，得到白色固體產(chǎn)物2i（79.2 g，產(chǎn)率93%）。TLC條件：Merck硅膠60F254，二氯甲烷-甲醇（90:10），Rf=0.32。

參考文獻(xiàn)：

[1] Patent: WO2005/80354, 2005, A1. Location in patent: Page/Page column 19

[2] Patent: US2008/167313, 2008, A1. Location in patent: Page/Page column 7

[3] Patent: WO2004/74266, 2004, A1. Location in patent: Page 52

[4] Patent: WO2006/15985, 2006, A1. Location in patent: Page/Page column 62

[5] Bioorganic and Medicinal Chemistry Letters, 2017, vol. 27, # 8, p. 1727 - 1730

5-溴-6-氮尿嘧啶 上下游產(chǎn)品信息

上游原料

下游產(chǎn)品

5-溴-6-氮尿嘧啶 生產(chǎn)廠家

5-溴-6-氮尿嘧啶 圖譜信息:

4956-05-2, 5-溴-6-氮尿嘧啶 相關(guān)搜索:

• ADVANCED INT.
• Ring Systems
• Halides
• Heterocycles series
• 生化試劑
• 中間體產(chǎn)品
• 定制
• 合成材料中間體
• 合成
• C3H2BrN3O2
• 4959-05-2
• 4956-5-2
• 6-溴-1,2,4-三嗪-3,5(2H,4H)-二酮
• 5-溴-6-氮尿嘧啶
• 5-溴-6-氮雜-2,6-二酮嘧啶
• 5-溴-6-氮雜尿嘧啶
• 4956-05-2
• 5-BROMO-6-AZAURACIL
• 6-Bromo-1,2,4-triazin-3,5(2H,4H)-dione
• 6-broMo-1,2,4-triazine-3,5-diol
• 6-BROMO-1,2,4-TRIAZINE-3,5(2H,4H)-DIONE
• 1,2,4-Triazine-3,5(2H,4H)-dione, 6-bromo-
• 6-Bromo-1,2,4-triazine-3,5(2H,4H)-dione 96%
• 6-bromo-2H-1,2,4-triazine-3,5-quinone
• 6-Bromo-1,2,4-triazine-3,5(2H,4H)
• 6-Bromo-3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine, 5-Bromo-6-azauracil
• 6-Bromo-1,2,4-triazine-3,5(2H,4H)-dione, 5-Bromo-6-azauracil
• 6-bromo-1,2,4-triazine-3,5(2H,4H)-dione(SALTDATA: FREE)
• 5-BROMO-6-AZAURACIL ,97%
• IFLAB-BB F1207-0035
• AURORA 14997
• 6-BROMO-2H-[1,2,4]TRIAZINE-3,5-DIONE
• 6-BROMO-2,3,4,5-TETRAHYDRO-1,2,4-TRIAZINE-3,5-DIONE
• 4h)-dione,6-bromo-as-triazine-5(2h
• VITAS-BB TBB000521