鹽酸氯吡胺
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- CAS號:
- 6170-42-9
- 英文名:
- Chloropyramine hydrochloride
- 英文別名:
- CHLOROPYRAMINE HCL;Chloropyramine HCI;Nilfan;Alergosan;Halopyramine hydrochloride;CHLOROPYRAMINE HYDROCHLORIDE;CHLOROPYRAMINE MONOHYDROCHLORIDE;Chloropyramine hydrochloride salt;3-chloro-2H-pyran-2-amine hydrochloride;Chloropyramine hydrochloride, 10 mM in DMSO
- 中文名:
- 鹽酸氯吡胺
- 中文別名:
- 鹽酸氯吡胺;氯吡胺鹽酸鹽;鹽酸氯吡胺鹽;鹽酸氯吡拉敏;氯吡拉敏鹽酸鹽;鹽酸氯吡胺,10 MM DMSO 溶液;N-對氯芐基-N′,N′-二甲基-N-(2-吡啶基)乙二胺;N-(4-氯芐基)-N,N’-二甲基-N-2-吡啶基-1,2-乙二胺;N-(4-氯芐基)-N',N'-二甲基-N-2-吡啶基-1,2-乙二胺鹽酸鹽;N1-(4-氯芐基)-N2,N2-二甲基-N1-(吡啶-2-基)乙烷-1,2-二胺鹽酸鹽
- CBNumber:
- CB4495475
- 分子式:
- C16H21Cl2N3
- 分子量:
- 326.26
- MOL File:
- 6170-42-9.mol
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鹽酸氯吡胺化學(xué)性質(zhì)
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熔點:
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172-174°
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儲存條件:
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Inert atmosphere,Room Temperature
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溶解度:
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Chloroform (Slightly), Methanol (Slightly), Water (Slightly)
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形態(tài):
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Solid
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顏色:
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White to Off-White
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主要應(yīng)用:
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forensics and toxicology
pharmaceutical (small molecule)
veterinary-
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InChI:
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1S/C16H20ClN3.ClH/c1-19(2)11-12-20(16-5-3-4-10-18-16)13-14-6-8-15(17)9-7-14;/h3-10H,11-13H2,1-2H3;1H
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InChIKey:
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VEYWWAGBHABATA-UHFFFAOYSA-N
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SMILES:
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Cl.CN(C)CCN(Cc1ccc(Cl)cc1)c2ccccn2
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CAS 數(shù)據(jù)庫:
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6170-42-9(CAS DataBase Reference)
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鹽酸氯吡胺性質(zhì)、用途與生產(chǎn)工藝
Chloropyramine hydrochloride 是一種組胺受體 H1 (histamine receptor H1) 拮抗劑，它也能抑制 VEGFR-3 和 FAK 的生化功能。
BT474 cells are highly sensitive to Chloropyramine hydrochloride (compound 1) treatment, whereby 1 μM concentrations cause a 40% reduction of viability after 48 h of treatment. It is found that at 1 μM concentrations of Chloropyramine hydrochloride, viability of control MCF7-pcDNA3 cells is significantly higher than the viability of MCF7-VEGFR-3 cells (P<0.01) and at 10 μM concentration this difference reaches twofold (P<0.001). In the BT474 cells treatment with Chloropyramine hydrochloride also leads to a concentration-dependent decrease of cell proliferation. When treatment with Chloropyramine hydrochloride is continued for 48 h, the breast cancer cells that overexpressed VEGFR-3 undergo apoptosis. This effect is dose-dependent, with 10 μM Chloropyramine hydrochloride inducing apoptosis in more than 60% of BT474 cells. In our model cell lines MCF7-pcDNA3 and MCF7-VEGFR-3, treatment with 10 μM Chloropyramine hydrochloride for 48 h leads to a 4-fold increase in apoptotic cell death in the cell line that overexpressed VEGFR-3 (18% versus 76 % respectively).
Chloropyramine hydrochloride causes a dramatic reduction of tumor growth in both model systems whereby the tumor size in the treated groups is approximately 20% of the tumor size in vehicle control groups. Doxorubicin administered at 3 mg/kg causes approximately 60% reduction of tumor growth, but has no effect on tumor growth at 0, 3 mg/kg. In contrast, there is a modest effect of Chloropyramine hydrochloride alone (50% reduction of tumor growth). The low-dose combination of Chloropyramine hydrochloride and doxorubicin has a prolonged anti-tumor effect (85% reduction of tumor growth) that is greater than either drug alone.
化學(xué)性質(zhì)
類白色至白色結(jié)晶性粉末。熔點168-172℃。
用途
抗過敏藥。
用途
抗過敏原料藥
鹽酸氯吡胺
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS編號 | 包裝 | 價格 |
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| 2026/06/05 | HY-B1305R | 鹽酸氯吡胺
Chloropyramine hydrochloride (Standard) | 6170-42-9 | 5 mg | 300元 |
| 2026/06/05 | HY-B1305R | 鹽酸氯吡胺
Chloropyramine hydrochloride (Standard) | 6170-42-9 | 10 mg | 500元 |
6170-42-9, 鹽酸氯吡胺 相關(guān)搜索:
- 抑制劑
- 高端化學(xué)
- 醫(yī)藥原料
- 小分子抑制劑
- CH
- Analytical Standards
- Analytical Chromatography Product Catalog
- Alphabetic
- C16H20ClN3ClH
- C16H20ClN3HCl
- 170-42-9
- 鹽酸氯吡拉敏
- 鹽酸氯吡胺,10 MM DMSO 溶液
- N1-(4-氯芐基)-N2,N2-二甲基-N1-(吡啶-2-基)乙烷-1,2-二胺鹽酸鹽
- 鹽酸氯吡胺鹽
- N-對氯芐基-N′,N′-二甲基-N-(2-吡啶基)乙二胺
- 氯吡拉敏鹽酸鹽
- 氯吡胺鹽酸鹽
- N-(4-氯芐基)-N,N’-二甲基-N-2-吡啶基-1,2-乙二胺
- 鹽酸氯吡胺
- N-(4-氯芐基)-N',N'-二甲基-N-2-吡啶基-1,2-乙二胺鹽酸鹽
- 6170-42-9
- CHLOROPYRAMINE HCL
- Chloropyramine hydrochloride, 10 mM in DMSO
- N'-[(4-chlorophenyl)methyl]-N,N-dimethyl-N'-pyridin-2-ylethane-1,2-diamine
- N'-[(4-chlorophenyl)methyl]-N,N-dimethyl-N'-pyridin-2-ylethane-1,2-diamine,hydrochloride
- Vascular endothelial growth factor receptor,FAK,inhibit,PTK2,Chloropyramine hydrochloride,VEGFR,Chloropyramine,Focal adhesion kinase,PTK2 protein tyrosine kinase 2,Histamine Receptor,Inhibitor
- Chloropyramine HCI
- Alergosan
- Halopyramine hydrochloride
- Nilfan
- Chloropyramine hydrochloride salt
- 3-chloro-2H-pyran-2-amine hydrochloride
- N-[(4-chlorophenyl)methyl]-N’,N’-dimethyl-N-2-pyridinyl-1,2-ethanediamine
- N1-(4-Chlorobenzyl)-N2,N2-dimethyl-N1-(pyridin-2-yl)ethane-1,2-diamine hydrochloride
- N-P-CHLOROBENZYL-N',N'-DIMETHYL-N-[2-PYRIDYL]LETHYLENEDIAMINE HYDROCHLORIDE
- N-P-CHLOROBENZYL-N',N'-DIMETHYL-N-[2-PYRIDYL]ETHYLENEDIAMINE HYDROCHLORIDE
- N-P-CHLOROBENZYL-N,N-DIMETHYL-N-(2-PYRIDYL)ETHYLENEDIAMINE HYDROCHLORIDE
- CHLOROPYRAMINE MONOHYDROCHLORIDE
- CHLOROPYRAMINE HYDROCHLORIDE