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6170-42-9

中文名稱 鹽酸氯吡胺
英文名稱 Chloropyramine hydrochloride
CAS 6170-42-9
EINECS 編號 228-216-2
分子式 C16H21Cl2N3
MDL 編號 MFCD00079009
分子量 326.26
MOL 文件 6170-42-9.mol
更新日期 2023/03/20 15:41:19
6170-42-9 結(jié)構(gòu)式 6170-42-9 結(jié)構(gòu)式

基本信息

中文別名
N-(4-氯芐基)-N',N'-二甲基-N-2-吡啶基-1,2-乙二胺鹽酸鹽
鹽酸氯吡胺
N-(4-氯芐基)-N,N’-二甲基-N-2-吡啶基-1,2-乙二胺
氯吡胺
氯吡胺鹽酸鹽
英文別名
CHLOROPYRAMINE HCL
CHLOROPYRAMINE HYDROCHLORIDE
CHLOROPYRAMINE MONOHYDROCHLORIDE
N-P-CHLOROBENZYL-N,N-DIMETHYL-N-(2-PYRIDYL)ETHYLENEDIAMINE HYDROCHLORIDE
N-P-CHLOROBENZYL-N',N'-DIMETHYL-N-[2-PYRIDYL]ETHYLENEDIAMINE HYDROCHLORIDE
N-P-CHLOROBENZYL-N',N'-DIMETHYL-N-[2-PYRIDYL]LETHYLENEDIAMINE HYDROCHLORIDE
Chloropyramine HCI
N-[(4-chlorophenyl)methyl]-N’,N’-dimethyl-N-2-pyridinyl-1,2-ethanediamine
所屬類別
分析化學(xué):法醫(yī)和獸醫(yī)標(biāo)準(zhǔn)品

物理化學(xué)性質(zhì)

外觀性狀類白色至白色結(jié)晶性粉末。熔點168-172℃。
熔點172-174°
儲存條件Inert atmosphere,Room Temperature
溶解度Chloroform (Slightly), Methanol (Slightly), Water (Slightly)
形態(tài)neat
顏色White to Off-White
主要應(yīng)用forensics and toxicology
pharmaceutical (small molecule)
veterinary
InChI1S/C16H20ClN3.ClH/c1-19(2)11-12-20(16-5-3-4-10-18-16)13-14-6-8-15(17)9-7-14;/h3-10H,11-13H2,1-2H3;1H
InChIKeyVEYWWAGBHABATA-UHFFFAOYSA-N
SMILESCl.CN(C)CCN(Cc1ccc(Cl)cc1)c2ccccn2
CAS 數(shù)據(jù)庫6170-42-9(CAS DataBase Reference)

安全數(shù)據(jù)

危險性符號(GHS)有害 (GHS07)
GHS07
警示詞警告
危險性描述H302
WGK Germany3
存儲類別11 - Combustible Solids

應(yīng)用領(lǐng)域

用途一
抗過敏藥。

知名試劑公司產(chǎn)品信息

鹽酸氯吡胺價格(試劑級)
報價日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價格
2026/07/06S5670鹽酸氯吡胺
Chloropyramine hydrochloride
6170-42-925mg795.31元
2026/06/05HY-B1305R鹽酸氯吡胺
Chloropyramine hydrochloride (Standard)
6170-42-95 mg300元
2026/06/05HY-B1305R鹽酸氯吡胺
Chloropyramine hydrochloride (Standard)
6170-42-910 mg500元

常見問題列表

生物活性
Chloropyramine hydrochloride 是一種組胺受體 H1 (histamine receptor H1) 拮抗劑,它也能抑制 VEGFR-3 和 FAK 的生化功能。
靶點

VEGFR-3

體外研究

BT474 cells are highly sensitive to Chloropyramine hydrochloride (compound 1) treatment, whereby 1 μM concentrations cause a 40% reduction of viability after 48 h of treatment. It is found that at 1 μM concentrations of Chloropyramine hydrochloride, viability of control MCF7-pcDNA3 cells is significantly higher than the viability of MCF7-VEGFR-3 cells (P<0.01) and at 10 μM concentration this difference reaches twofold (P<0.001). In the BT474 cells treatment with Chloropyramine hydrochloride also leads to a concentration-dependent decrease of cell proliferation. When treatment with Chloropyramine hydrochloride is continued for 48 h, the breast cancer cells that overexpressed VEGFR-3 undergo apoptosis. This effect is dose-dependent, with 10 μM Chloropyramine hydrochloride inducing apoptosis in more than 60% of BT474 cells. In our model cell lines MCF7-pcDNA3 and MCF7-VEGFR-3, treatment with 10 μM Chloropyramine hydrochloride for 48 h leads to a 4-fold increase in apoptotic cell death in the cell line that overexpressed VEGFR-3 (18% versus 76 % respectively).

體內(nèi)研究

Chloropyramine hydrochloride causes a dramatic reduction of tumor growth in both model systems whereby the tumor size in the treated groups is approximately 20% of the tumor size in vehicle control groups. Doxorubicin administered at 3 mg/kg causes approximately 60% reduction of tumor growth, but has no effect on tumor growth at 0, 3 mg/kg. In contrast, there is a modest effect of Chloropyramine hydrochloride alone (50% reduction of tumor growth). The low-dose combination of Chloropyramine hydrochloride and doxorubicin has a prolonged anti-tumor effect (85% reduction of tumor growth) that is greater than either drug alone.

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