MIDAGLIZOLE HYDROCHLORIDE
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- CAS號:
- 79689-25-1
- 英文名:
- 2-[2-(4,5-dihydro-1H-imidazol-2-yl)-1-phenyl-ethyl]pyridine dihydrochl oride
- 英文別名:
- Midaglizole hydrochloride;Midaglizole hydrochloride, 10 mM in DMSO;2-[2-(4,5-dihydro-1H-imidazol-2-yl)-1-phenyl-ethyl]pyridine dihydrochl oride;Pyridine,2-[2-(4,5-dihydro-1H-imidazol-2-yl)-1-phenylethyl]-, hydrochloride (1:2)
- 中文名:
- MIDAGLIZOLE HYDROCHLORIDE
- 中文別名:
- 咪格列唑鹽酸鹽;化合物 T11015;咪格列唑鹽酸鹽,10 MM DMSO 溶液
- CBNumber:
- CB91256447
- 分子式:
- C16H19Cl2N3
- 分子量:
- 0
- MOL File:
- 79689-25-1.mol
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MIDAGLIZOLE HYDROCHLORIDE化學(xué)性質(zhì)
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儲存條件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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形態(tài):
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Solid
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顏色:
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White to off-white
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MIDAGLIZOLE HYDROCHLORIDE性質(zhì)、用途與生產(chǎn)工藝
Midaglizole hydrochloride (DG5128) 是有效的 α2-腎上腺素受體拮抗劑。Midaglizole hydrochloride (DG5128) 對 α2-腎上腺素能受體的親和力 (pKi= 6.28) 比 α1-腎上腺素能受體高 7.4 倍。
pKi :6.28 (α2-adrenoceptor)
Midaglizole (DG-5128) at concentrations up to 10 μM inhibits [
3
H]clonidine binding more effectively than it doed [
3
H]prazosin binding in rat cerebral cortex membranes. The mode of inhibition is homogeneous and consistent with the law of simple mass action. The EC
50
values for stimulation of insulin release from rat islets and the MIN6 β-cell line induced by Midaglizole are 200 nM and 24 μM, respectively. The IC
50
values for K
ATP
current inhibition induced by Midaglizole are 3.8 μM and 4.4 uM for Kir6.2 and Kir6.2/SUR1 , respectively.
Midaglizole (3 and 30 mg/kg, i.v.) increases blood pressure in pithed rats.
MIDAGLIZOLE HYDROCHLORIDE
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS編號 | 包裝 | 價格 |
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| 2026/06/05 | HY-U00165 | Midaglizole hydrochloride | 79689-25-1 | 1 mg | 1035元 |
| 2026/06/05 | HY-U00165 | MIDAGLIZOLE HYDROCHLORIDE
Midaglizole hydrochloride | 79689-25-1 | 5 mg | 2663元 |
MIDAGLIZOLE HYDROCHLORIDE
生產(chǎn)廠家
MIDAGLIZOLE HYDROCHLORIDE 圖譜信息:
79689-25-1, MIDAGLIZOLE HYDROCHLORIDE 相關(guān)搜索:
- 抑制劑
- C16H19Cl2N3
- 咪格列唑鹽酸鹽,10 MM DMSO 溶液
- 化合物 T11015
- 咪格列唑鹽酸鹽
- 79689-25-1
- Midaglizole hydrochloride, 10 mM in DMSO
- Pyridine,2-[2-(4,5-dihydro-1H-imidazol-2-yl)-1-phenylethyl]-, hydrochloride (1:2)
- Midaglizole hydrochloride
- 2-[2-(4,5-dihydro-1H-imidazol-2-yl)-1-phenyl-ethyl]pyridine dihydrochl oride