3-Butylidenphthalid
|
|
|
- CAS-Nr.
- 551-08-6
- Bezeichnung:
- 3-Butylidenphthalid
- Englisch Name:
- 3-Butylidenephthalide
- Synonyma:
- 3-BUTYLIDENEPHTHALIDE;BUTYLIDENE PHTHALIDE;Bdph;FEMA 3333;N-BUTYLIDENEPHTHALIDE;ligusticumlactone;3-butylidene-phthalid;3-Butylideneisobenzofuran-1(3H)-one;Ai3-37306;NSC 325307
- CBNumber:
- CB0173298
- Summenformel:
- C12H12O2
- Molgewicht:
- 188.22
- MOL-Datei:
- 551-08-6.mol
|
3-Butylidenphthalid Eigenschaften
- Schmelzpunkt:
- 82.5°C
- Siedepunkt:
- 139-142 °C/5 mmHg (lit.)
- Dichte
- 1.103 g/mL at 25 °C (lit.)
- FEMA
- 3333 | 3-BUTYLIDENEPHTHALIDE
- Brechungsindex
- n20/D 1.577(lit.)
- Flammpunkt:
- >230 °F
- storage temp.
- Refrigerator
- L?slichkeit
- Chloroform (Slightly), Ethyl Acetate (Slightly)
- Aggregatzustand
- Oil
- Farbe
- Colourless to Yellow
- Geruch (Odor)
- at 10.00 % in dipropylene glycol. herbal lovage celery
- Geruchsart
- herbal
- Biologische Quelle
- synthetic
- JECFA Number
- 1170
- BRN
- 5145
- Major Application
- flavors and fragrances
- Kosmetik-Inhaltsstoffe Funktionen
- PERFUMING
- InChI
- 1S/C12H12O2/c1-2-3-8-11-9-6-4-5-7-10(9)12(13)14-11/h4-8H,2-3H2,1H3/b11-8-
- InChIKey
- WMBOCUXXNSOQHM-FLIBITNWSA-N
- SMILES
- CCC\C=C1/OC(=O)c2ccccc12
- LogP
- 3.72
- CAS Datenbank
- 551-08-6(CAS DataBase Reference)
- EPA chemische Informationen
- 1(3H)-Isobenzofuranone, 3-butylidene- (551-08-6)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
Xn |
|
|
| R-S?tze: |
22 |
|
|
| S-S?tze: |
23 |
|
|
| WGK Germany |
2 |
|
|
| RTECS-Nr. |
TI3692500 |
|
|
| TSCA |
TSCA listed |
|
|
| Speicherklasse |
10 - Combustible liquids |
|
|
| Hazard Classifications |
Acute Tox. 4 Oral
Aquatic Chronic 2 |
|
|
| Bildanzeige (GHS) |
|
| Alarmwort |
Warnung
|
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
|
P264, P270, P301+P312, P330, P501 |
|
| Sicherheit |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P270 |
Bei Gebrauch nicht essen, trinken oder rauchen. |
| P330 |
Mund ausspülen. |
|
3-Butylidenphthalid Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R22:Gesundheitssch?dlich beim Verschlucken.
S-S?tze Betriebsanweisung:
S23:Gas/Rauch/Dampf/Aerosol nicht einatmen(geeignete Bezeichnung(en) vom Hersteller anzugeben).
Chemische Eigenschaften
3-Butylidenephthalide has a pervasive warm spicy aroma.
Occurrence
Reported as occurring naturally in the fruits and roots of Ligusticum acutilobum and lovage (Levisticum officinale)
seeds, roots and leaves.
Verwenden
3-Butylidenephthalide is a phthalide derivative useful for control of sensation disorder and olfaction disorder.
Definition
ChEBI: A gamma-lactone that is phthalide substituted by a butylidene group at position 3. Isolated from Ligusticum porteri, it exhibits hypoglycemic activity.
Allgemeine Beschreibung
3-Butylidenephthalide is a bioactive phthalide compound of Chuanxiong rhizoma, a Chinese herbal medicine used for treating headache obtained from the root of
Ligusticum chuanxiong Hort.
Cytotoxicity
The anti-proliferative effects of 3-Butylidenephthalide (n-Butylidenephthalide; BP) on cells from GBM, neuroblastoma, lung cancer, melanoma, teratoma, leukemia, breast cancer and hepatocellular carcinoma, as well as from normal fibroblast and vascular endothelial cells, were determined. The IC50 values of BP after a 48 h incubation with tumor cell lines (IC50: 15–67 μg/mL) were significantly lower than the values for normal fibroblast cells (IC50: >100 μg/mL, p < 0.0001) or carmustine (BCNU)-treated tumor cells (IC50: 40 ～ 100 μg/mL, p < 0.001; Table 1). In the two normal cell types, vascular endothelial cells (IC50 = 25.0 ± 2.0 μg/mL) were more sensitive to BP than fibroblast cells (IC50 > 100 μg/mL) (p < 0.0001). These experiments showed that BP could induce high cytotoxicity against brain and other tumour cells but only low or no cytotoxicity against normal fibroblast cells.
Sicherheitsprofil
Moderately toxic by
ingestion. A skin irritant. When heated to
decomposition it emits acrid smoke and
irritating fumes.
3-Butylidenphthalid Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
3-Butylidenphthalid Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 346)Lieferanten
551-08-6(3-Butylidenphthalid)Verwandte Suche:
- 1(3H)-Isobenzofuranone,3-butylidene-
- 3-butylidene-1(3h)-isobenzofuranon
- 3-butylidene-1(3H)-Isobenzofuranone
- 3-BUTYLIDENEPHTHALIDE 96+%
- n-Butylidenephthalide,95%
- 3-Butylidene-1,3-dihydroisobenzofuran-1-one
- n-Butylidenephthalide, (E)+(Z), 95%
- 3-Butylidene Phthalide (Cis Trans Mixture)
- (Z)-3-butylidenephthalide
- Phthalide,3-butylidene-(6CI,7CI,8CI)
- NSC 325307
- Ai3-37306
- Einecs 208-991-3
- n-Butylidenephthalide, E- and Z-, 95%
- 3-Butylidene phthalide - mixture ofcisandtransisomers
- Butylphthalide Impurity 2
- Butylphthalide Impurity 23
- 3-Butylphthalide Impurity 21
- Butyphthalide impurity 20
- 3-Butylidenphthalid
- Butenylphthalide
- N-BUTYLIDENEPHTHALID
- BUTYLIDENE PTHALIDE
- 3-butyidenephthalide
- 3-n-butenylphthalide
- (3E)-3-butylidene-2-benzofuran-1-one
- 3-BUTYLIDENEPHTHALIDE
- 3-butylidene-phthalid
- 3-Butylideneisobenzofuran-1(3H)-one
- Butylphthalide Impurity 27 (mixture of cis and trans isomers)
- Butylphthalein impurity 20
- 3-Butylidenephthalide, 10 mM in DMSO
- Bdph
- BUTYLIDENE PHTHALIDE
- FEMA 3333
- ligusticumlactone
- N-BUTYLIDENEPHTHALIDE
- 551-08-6
- 555-08-6
- 0551-08-06
- Aromatics
- Heterocycles
- Intermediates & Fine Chemicals
- Pharmaceuticals
- chemical reagent
- pharmaceutical intermediate
- phytochemical
- reference standards from Chinese medicinal herbs (TCM).
- standardized herbal extract
- A-B
- Alphabetical Listings
- Flavors and Fragrances
- Phthalides
