2-Methyl-pyrazin Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R10:Entzündlich.
R22:Gesundheitssch?dlich beim Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-S?tze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S16:Von Zündquellen fernhalten - Nicht rauchen.
Beschreibung
2-Methylpyrazine has an odor threshold in water variously
reported at 60,000 or 105,000 ppb. May be prepared from the
corresponding carboxylic acid; by catalytic dehydrogenation of
2-methyl-piperazine; by condensation of methylglyoxal with ethylenediamine.
Chemische Eigenschaften
2-Methylpyrazine has a nutty, cocoa, green, roasted, chocolate, meaty odor.
Occurrence
Reported found in bakery products, roasted barley, cocoa products, coffee, dairy products, cooked meats,
peanuts, filberts, pecans, popcorn, potato chips, rum and whiskey, soy product, roasted filberts, roasted almonds, guava, papaya,
asparagus, kohlrabi, baked and fried potato, milk, boiled egg, smoked fish, beer, coffee, sesame seed, rice, sukiyaki, buckwheat,
sweet corn, corn tortillas, malt, wort, wild rice, okra, crayfish, clam, squid and maté.
Verwenden
2-Methylpyrazine is used as flavoring agents in bread fresh bread, butter, chocolate, chocolate cocoa, coffee, meat roasted, nut almond.
synthetische
From corresponding carboxylic acid; by catalytic dehydrogenation of 2-methyl-piperazine; by condensation of methylglyoxal with ethylenediamine
Allgemeine Beschreibung
2-Methylpyrazine is an alkyl-substituted pyrazine used as a key intermediate in the synthesis of pyrazineamide, an anti-tubercular drug.
Sicherheitsprofil
Moderately toxic by
ingestion and intraperitoneal routes.
Mutation data reported. Flammable liquid
when exposed to heat, sparks, or flame. Can react with oxidizing materials. To fight fire,
use water spray, foam, dry chemical, CO2.
When heated to decomposition it emits
highly toxic fumes of NOx.
Synthese
2-Methylpyrazine is mostly synthesized via cyclization of ethylenediamine (ED) and 1,2-propylene glycol (PG)
[1].
l?uterung methode
Purify it via the picrate and distil the free base. The picrate has m133-134o(from EtOH). [Wiggins & Wise J Chem Soc 4780 1956, Beilstein 23 III/IV 911, 23/5 V 386.]
2-Methyl-pyrazin Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Methylglyoxal
1,2-Diaminoethan
2-Methylpiperazin
Pyrazine, 2,3-dimethyl-5-(1Z)-1-propen-1-yl-
Pyrazine, 3,5-dimethyl-2-(1Z)-1-propen-1-yl-
3-Ethyl-2,5-dimethylpyrazin
2-Ethyl-3,5-dimethylpyrazin
2-Ethyl-3-methylpyrazin
2,3-Dimethylpyrazin
2,3,5-Trimethylpyrazin
Downstream Produkte
