2-メチルピラジン 化學特性,用途語,生産方法
外観
無色～わずかにうすい黃色, 澄明の液體
溶解性
水に易溶, 有機溶媒に可溶。水、エタノール及びアセトンに極めて溶けやすい。
用途
コーヒー,ポテト,ナッツ類のばい焼フレーパー. ミートプレーパー.(有機化合物辭典 (1985))
説明
2-Methylpyrazine has an odor threshold in water variously
reported at 60,000 or 105,000 ppb. May be prepared from the
corresponding carboxylic acid; by catalytic dehydrogenation of
2-methyl-piperazine; by condensation of methylglyoxal with ethylenediamine.
化學的特性
2-Methylpyrazine has a nutty, cocoa, green, roasted, chocolate, meaty odor.
天然物の起源
Reported found in bakery products, roasted barley, cocoa products, coffee, dairy products, cooked meats,
peanuts, filberts, pecans, popcorn, potato chips, rum and whiskey, soy product, roasted filberts, roasted almonds, guava, papaya,
asparagus, kohlrabi, baked and fried potato, milk, boiled egg, smoked fish, beer, coffee, sesame seed, rice, sukiyaki, buckwheat,
sweet corn, corn tortillas, malt, wort, wild rice, okra, crayfish, clam, squid and maté.
使用
2-Methylpyrazine is used as flavoring agents in bread fresh bread, butter, chocolate, chocolate cocoa, coffee, meat roasted, nut almond.
製造方法
From corresponding carboxylic acid; by catalytic dehydrogenation of 2-methyl-piperazine; by condensation of methylglyoxal with ethylenediamine
一般的な説明
2-Methylpyrazine is an alkyl-substituted pyrazine used as a key intermediate in the synthesis of pyrazineamide, an anti-tubercular drug.
安全性プロファイル
Moderately toxic by
ingestion and intraperitoneal routes.
Mutation data reported. Flammable liquid
when exposed to heat, sparks, or flame. Can react with oxidizing materials. To fight fire,
use water spray, foam, dry chemical, CO2.
When heated to decomposition it emits
highly toxic fumes of NOx.
合成
2-Methylpyrazine is mostly synthesized via cyclization of ethylenediamine (ED) and 1,2-propylene glycol (PG)
[1].
純化方法
Purify it via the picrate and distil the free base. The picrate has m133-134o(from EtOH). [Wiggins & Wise J Chem Soc 4780 1956, Beilstein 23 III/IV 911, 23/5 V 386.]
2-メチルピラジン 上流と下流の製品情報
原材料
1,2-プロパンジオン
エチレンジアミン (無水)
2-メチルピペラジン
Pyrazine, 2,3-dimethyl-5-(1Z)-1-propen-1-yl-
Pyrazine, 3,5-dimethyl-2-(1Z)-1-propen-1-yl-
2-エチル-3,6-ジメチルピラジン
2-エチル-3,5-ジメチルピラジン
2-エチル-3-メチルピラジン
2,3-ジメチルピラジン
2,3,5-トリメチルピラジン
準備製品