TMS
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- CAS-Nr.
- 24144-92-1
- Englisch Name:
- TMS
- Synonyma:
- CS-961;SMB 00388;TMS, >=98%;TMS, 10 mM in DMSO;5'-tetramethoxystilbene;3,5,2’,4’-Tetramethoxystilbene;2,3',4,5'-TETRAMETHOXYSTILBENE;2,4,3',5'-Tetramethoxystilbene;(E)-2,3',4,5'-TETRAMETHOXYSTILBENE;TMS (2,4,3',5'-tetramethoxystilbene)
- CBNumber:
- CB0347220
- Summenformel:
- C18H20O4
- Molgewicht:
- 300.35
- MOL-Datei:
- 24144-92-1.mol
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TMS Eigenschaften
- Schmelzpunkt:
- 78-79 °C
- Siedepunkt:
- 459.9±40.0 °C(Predicted)
- Dichte
- 1.117±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- L?slichkeit
- DMF: 30 mg/ml; DMF:PBS (pH 7.2) (1:1): 500 μg/ml; DMSO: 20 mg/ml; Ethanol: 400 μg/ml
- Aggregatzustand
- Powder
- Farbe
- Light yellow to yellow
- InChI
- 1S/C18H20O4/c1-19-15-8-7-14(18(12-15)22-4)6-5-13-9-16(20-2)11-17(10-13)21-3/h5-12H,1-4H3/b6-5+
- InChIKey
- JDBCWSHYEQUBLW-AATRIKPKSA-N
- SMILES
- COC1=CC(OC)=CC=C1/C=C/C2=CC(OC)=CC(OC)=C2
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| WGK Germany |
WGK 3 |
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| Speicherklasse |
11 - Combustible Solids |
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| Hazard Classifications |
Acute Tox. 4 Oral |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
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P264, P270, P301+P312, P330, P501 |
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| Sicherheit |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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TMS Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
CYP1B1 is mainly an extrahepatic enzyme which oxidatively metabolizes both endogenous (steroids; eicosanoids) and exogenous xenobiotics such aspolyaromatic hydrocarbons. TMS is a potent and selective inhibitor of CYP1B1, with an IC50 of 6 nM. It is 50-fold selective for the inhibition of CYP1B1 versus CYP1A1, making it a useful tool to differentiate between various CYP450 families. In cultured human colon cancer cells, TMS induces apoptosis and inhibits cell growth with an IC50 of 0.8 μg/ml.
Biologische Aktivit?t
Potent, selective and competitive inhibitor of cytochrome P450 1B1, an enzyme overexpressed in certain tumors (IC 50 = 6 nM). 50- and 520-fold selective over P450 1A1 and 1A2 respectively. Inhibits cancer cell growth in vitro .
TMS Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
TMS Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 107)Lieferanten
24144-92-1()Verwandte Suche:
- (E)-2,3',4,5'-TETRAMETHOXYSTILBENE
- 2,3',4,5'-TETRAMETHOXYSTILBENE
- 1-[(1E)-2-(3,5-DIMETHOXYPHENYL)ETHENYL]-2,4-DIMETHOXY-BENZENE
- 1-[2,(3,5-DIMETHOXYPHENYL)ETHENYL]-2,4-DIMETHOXYBENZENE
- 3,5,2’,4’-Tetramethoxystilbene
- Benzene, 1-[(1E)-2-(3,5-diMethoxyphenyl)ethenyl]-2,4-diMethoxy-
- (E)-1-(3,5-Dimethoxystyryl)-2,4-dimethoxybenzene
- TMS, >=98%
- TMS - Trans-2,3',4,5'-tetramethoxystilbene
- CS-961
- 5'-tetramethoxystilbene
- SMB 00388
- 2,4,3',5'-Tetramethoxystilbene
- (E)-2,3'',4,5''-Tetramethoxystilbene, CYP1B1 inhibitor
- TMS, 10 mM in DMSO
- (E)-2,3',4,5'-Tetramethoxystilbene, CYP1B1 inhibitor
- (E)-2,3',4,5'-Tetramethoxystilbene, CYP1B1 inhibitor
- TMS (2,4,3',5'-tetramethoxystilbene)
- 24144-92-1
- Antitumour
