ChemicalBook >?? ???? >TMS
TMS
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TMS ??
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- 78-79 °C
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- 459.9±40.0 °C(Predicted)
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- 1.117±0.06 g/cm3(Predicted)
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- Sealed in dry,Store in freezer, under -20°C
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- DMF: 30 mg/ml; DMF:PBS (pH 7.2) (1:1): 500 μg/ml; DMSO: 20 mg/ml; Ethanol: 400 μg/ml
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- Light yellow to yellow
- InChI
- 1S/C18H20O4/c1-19-15-8-7-14(18(12-15)22-4)6-5-13-9-16(20-2)11-17(10-13)21-3/h5-12H,1-4H3/b6-5+
- InChIKey
- JDBCWSHYEQUBLW-AATRIKPKSA-N
- SMILES
- COC1=CC(OC)=CC=C1/C=C/C2=CC(OC)=CC(OC)=C2
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- ?? ? ???? ?? (GHS)
| WGK ?? | WGK 3 | ||
|---|---|---|---|
| ???? ??? | 11 - Combustible Solids | ||
| Hazard Classifications | Acute Tox. 4 Oral |
TMS C??? ??, ??, ??
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CYP1B1 is mainly an extrahepatic enzyme which oxidatively metabolizes both endogenous (steroids; eicosanoids) and exogenous xenobiotics such aspolyaromatic hydrocarbons. TMS is a potent and selective inhibitor of CYP1B1, with an IC50 of 6 nM. It is 50-fold selective for the inhibition of CYP1B1 versus CYP1A1, making it a useful tool to differentiate between various CYP450 families. In cultured human colon cancer cells, TMS induces apoptosis and inhibits cell growth with an IC50 of 0.8 μg/ml.???? ??
Potent, selective and competitive inhibitor of cytochrome P450 1B1, an enzyme overexpressed in certain tumors (IC 50 = 6 nM). 50- and 520-fold selective over P450 1A1 and 1A2 respectively. Inhibits cancer cell growth in vitro .TMS ?? ?? ? ???
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TMS ?? ??
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| ??? | ?? | ??? | ?? | ?? ? | ?? |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 |
factory@coreychem.com | China | 29792 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471; |
sales@sarms4muscle.com | China | 10473 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 |
sales@invivochem.cn | United States | 6391 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 |
market18@leapchem.com | China | 24597 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; |
support@targetmol.com | United States | 39040 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 |
trendseenbio@gmail.com | China | 11680 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 |
masar@topule.com | China | 8467 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8615965530500 |
nickzhang@hangyubiotech.com | China | 9948 | 58 |
| Aladdin Scientific | |
tp@aladdinsci.com | United States | 57505 | 58 |
TMS ?? ??:
N,O-??(??????)??????? ????????-?6 ???? ???, ?-??, ?? ?? ?? ???-D8
4-NITROSTYRENE
1-TMS-1H-BENZOTRIAZOLE
Acetonitrile-d3
Tetrakis(trimethylsilyl)silane ((TMS)4Si )
Chloroform-d
ACETONE-D6
N,N-DIMETHYLFORMAMIDE-D7, 99.5 ATOM % D (CONTAINS 1% V/V TMS)
N-METHYL-N-TRIMETHYLSILYLHEPTAFLUOROBUTYRAMIDE (TMS REAGENT FOR GC USING FID) 95+%
PYRIDINE-D5
Methanol-d4
1-TMS-1H-BENZOTRIAZOLE
1-(TMS)ETHYNYLCYCLOHEXENE
Cytochrome P450 1B1 Inhibitor, TMS