CGP 55845

149184-22-5

CAS-Nr.: 149184-22-5

Englisch Name:: CGP 55845

Synonyma:: CGP 55845;CGP 55845 hydrochlor;CGP 55845 hydrochloride;CGP 55845 hydrochloride, GABAB antagonist;benzyl-[(2S)-3-[[(1S)-1-(3,4-dichlorophenyl)ethyl]amino]-2-hydroxypropyl]phosphinic acid;(2S)-3-[[(1S)-1-(3,4-DICHLOROPHENYL)ETHYL]AMINO-2-HYDROXYPROPYL](PHENYLMETHYL)PHOSPHINIC ACID;(2S)-3-[[(1S)-1-(3,4-Dichlorophenyl)ethyl]amino-2-hydroxypropyl](phenylmethyl)phosphinicacidhydrochloride

CBNumber:: CB0718390

Summenformel:: C18H23Cl3NO3P

Molgewicht:: 438.71

MOL-Datei:: 149184-22-5.mol

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Eigenschaften Sicherheit Verwendungswort Produktionsfirma 36

CGP 55845 Eigenschaften

storage temp.: room temp

L?slichkeit: DMSO: soluble5mg/mL, clear (warmed)

Aggregatzustand: powder

Farbe: white to beige

InChI: 1S/C18H22Cl2NO3P/c1-13(15-7-8-17(19)18(20)9-15)21-10-16(22)12-25(23,24)11-14-5-3-2-4-6-14/h2-9,13,16,21-22H,10-12H2,1H3,(H,23,24)/t13-,16-/m0/s1

InChIKey: ZODSPDOOCZZEIM-BBRMVZONSA-N

SMILES: [P](=O)(O)(C[C@@H](O)CN[C@@H](C)c2cc(c(cc2)Cl)Cl)Cc1ccccc1

Sicherheit

WGK Germany	3
RTECS-Nr.	SZ4680000
Speicherklasse	11 - Combustible Solids

CGP 55845 Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

CGP is a potent, selectie GABAB receptor antagonist.

Biologische Aktivit?t

Potent, selective GABA B receptor antagonist (IC 50 = 5 nM) that prevents agonist binding (pK i = 8.35) and inhibits GABA and glutamate release (pEC 50 values are 8.08 and 7.85 respectively). Inhibits GABA B responses to baclofen (IC 50 = 130 nM in an isoproterenol assay) and potentiates the hypoglycemic response to glucose in vitro .

Biochem/physiol Actions

CGP 55845 is a potent selective GABA-B receptor antagonist with an IC50 of 5 nM.

CGP 55845 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

CGP 55845 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 36)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
BOC Sciences	16314854226; +16314854226	inquiry@bocsci.com	United States	19853	58
Aladdin Scientific		tp@aladdinsci.com	United States	52923	58
3B Pharmachem (Wuhan) International Co.,Ltd.	18930552037	3bsc@sina.com	China	15838	69
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51395	80
EMMX Biotechnology LLC	888-539-0666	info@emmx.com	United States	8447	60
BOC Sciences	--	info@bocsci.com	USA	0	65
Energy Chemical	021-58432009 400-005-6266	marketing1@energy-chemical.com	China	44910	58
MedBioPharmaceutical Technology Inc	021-69568360 18916172912	order@med-bio.cn	China	8140	58
Shanghai Universal Biotech Co.,Ltd	15921930842 15921930842	yh-wang@univ-bio.com	China	25022	58
Xi'an Qiyue Biotechnology Co., Ltd.	400-400-6966-012-012 17778955912	2957605606@qq.com	China	3988	58

CGP 55845
(2S)-3-[[(1S)-1-(3,4-Dichlorophenyl)ethyl]amino-2-hydroxypropyl](phenylmethyl)phosphinicacidhydrochloride
CGP 55845 hydrochloride
(2S)-3-[[(1S)-1-(3,4-DICHLOROPHENYL)ETHYL]AMINO-2-HYDROXYPROPYL](PHENYLMETHYL)PHOSPHINIC ACID
benzyl-[(2S)-3-[[(1S)-1-(3,4-dichlorophenyl)ethyl]amino]-2-hydroxypropyl]phosphinic acid
CGP 55845 hydrochlor
CGP 55845 hydrochloride, GABAB antagonist
149184-22-5
C18H22Cl2NO3PHCl
C18H23Cl3NO3P
GABA/Glycine receptor

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