CGP 55845
- CAS No.
- 149184-22-5
- Chemical Name:
- CGP 55845
- Synonyms
- CGP 55845;CGP 55845 hydrochlor;CGP 55845 hydrochloride;CGP 55845 hydrochloride, GABAB antagonist;benzyl-[(2S)-3-[[(1S)-1-(3,4-dichlorophenyl)ethyl]amino]-2-hydroxypropyl]phosphinic acid;(2S)-3-[[(1S)-1-(3,4-DICHLOROPHENYL)ETHYL]AMINO-2-HYDROXYPROPYL](PHENYLMETHYL)PHOSPHINIC ACID;(2S)-3-[[(1S)-1-(3,4-Dichlorophenyl)ethyl]amino-2-hydroxypropyl](phenylmethyl)phosphinicacidhydrochloride
- CBNumber:
- CB0718390
- Molecular Formula:
- C18H23Cl3NO3P
- Molecular Weight:
- 438.71
- MDL Number:
- MOL File:
- 149184-22-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| CGP 55845 hydrochloride ≥98% (HPLC) | SML0594 | 5mg | $148 |
| CGP 55845 hydrochloride ≥98% (HPLC) | SML0594 | 25mg | $594 |
| CGP 55845 (hydrochloride) ≥98% | 21912 | 5mg | $119 |
| CGP 55845 (hydrochloride) ≥98% | 21912 | 10mg | $225 |
| CGP 55845 (hydrochloride) ≥98% | 21912 | 25mg | $532 |
| storage temp. | room temp |
|---|---|
| solubility | DMSO: soluble5mg/mL, clear (warmed) |
| form | powder |
| color | white to beige |
| InChI | 1S/C18H22Cl2NO3P/c1-13(15-7-8-17(19)18(20)9-15)21-10-16(22)12-25(23,24)11-14-5-3-2-4-6-14/h2-9,13,16,21-22H,10-12H2,1H3,(H,23,24)/t13-,16-/m0/s1 |
| InChIKey | ZODSPDOOCZZEIM-BBRMVZONSA-N |
| SMILES | [P](=O)(O)(C[C@@H](O)CN[C@@H](C)c2cc(c(cc2)Cl)Cl)Cc1ccccc1 |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| WGK Germany | 3 |
|---|---|
| RTECS | SZ4680000 |
| Storage Class | 11 - Combustible Solids |
CGP 55845 price More Price(26)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0594 | CGP 55845 hydrochloride ≥98% (HPLC) | 149184-22-5 | 5mg | $148 | 2026-04-30 | Buy |
| Sigma-Aldrich | SML0594 | CGP 55845 hydrochloride ≥98% (HPLC) | 149184-22-5 | 25mg | $594 | 2026-04-30 | Buy |
| Cayman Chemical | 21912 | CGP 55845 (hydrochloride) ≥98% | 149184-22-5 | 5mg | $119 | 2026-04-30 | Buy |
| Cayman Chemical | 21912 | CGP 55845 (hydrochloride) ≥98% | 149184-22-5 | 10mg | $225 | 2026-04-30 | Buy |
| Cayman Chemical | 21912 | CGP 55845 (hydrochloride) ≥98% | 149184-22-5 | 25mg | $532 | 2026-04-30 | Buy |
CGP 55845 Chemical Properties,Uses,Production
Uses
CGP is a potent, selectie GABAB receptor antagonist.
Biological Activity
Potent, selective GABA B receptor antagonist (IC 50 = 5 nM) that prevents agonist binding (pK i = 8.35) and inhibits GABA and glutamate release (pEC 50 values are 8.08 and 7.85 respectively). Inhibits GABA B responses to baclofen (IC 50 = 130 nM in an isoproterenol assay) and potentiates the hypoglycemic response to glucose in vitro .
Biochem/physiol Actions
CGP 55845 is a potent selective GABA-B receptor antagonist with an IC50 of 5 nM.
in vitro
antagonist cgp 55845a of the gabab receptor in the presence of cnqx and d(2)-2-amino-5-phosphonovaleric acid prevented the inhibitory postsynaptic potential-b and paired-pulse depression. [3].
IC 50
5 nm
storage
Room temperature
References
[1] waldmeier pc, wicki p, feldtrauer jj, mickel sj, bittiger h, baumann pa. gaba and glutamate release affected by gabab receptor antagonists with similar potency: no evidence for pharmacologically different presynaptic receptors. br j pharmacol. 1994 dec;113(4):1515-21.
[2] cunningham md, enna sj. evidence for pharmacologically distinct gabab receptors associated with camp production in rat brain. brain res. 1996 may 13;720(1-2):220-4.
[3] deisz ra. the gaba(b) receptor antagonist cgp 55845a reduces presynaptic gaba(b) actions in neocortical neurons of the rat in vitro. neuroscience. 1999;93(4):1241-9.
[4] zhang m, buttigieg j, nurse ca. neurotransmitter mechanisms mediating low-glucose signalling in cocultures and fresh tissue slices of rat carotid body. j physiol. 2007 feb 1;578(pt 3):735-50. epub 2006 nov 23.
[5] salah a, perkins kl. effects of subtype-selective group i mglur antagonists on synchronous activity induced by 4-aminopyridine/cgp 55845 in adult guinea pig hippocampal slices. neuropharmacology. 2008 jul;55(1):47-54. doi: 10.1016/j.neuropharm.2008.04.010. epub 2008 apr 23.
CGP 55845 Preparation Products And Raw materials
Raw materials
Preparation Products
CGP 55845 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19853 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52923 | 58 | |
| NANJING YINGWEN BIOTECHNOLOGY CO LTD | +8613382787392 | sales@aeechem.com | China | 10001 | 58 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15838 | 69 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51395 | 80 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8447 | 60 |
| BOC Sciences | -- | info@bocsci.com | USA | 0 | 65 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing1@energy-chemical.com | China | 44896 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8140 | 58 |
| Shanghai Universal Biotech Co.,Ltd | 15921930842 15921930842 | yh-wang@univ-bio.com | China | 25022 | 58 |
