2-Chloro-5-hydroxypyrimidine
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- CAS-Nr.
- 4983-28-2
- Englisch Name:
- 2-Chloro-5-hydroxypyrimidine
- Synonyma:
- 2-Chloropyrimidin-5-ol;Piribedil Impurity 17;2-Chloro-5-pyrimidinol;5-PyriMidinol,2-chloro-;2-Chloro-5-hydroxypyrimidine;2-Chloro-5-hydroxypyrimid...;2-Chloro-5-hydroxypyrimidine 98%;5-Pyrimidinol, 2-chloro- (7CI,8CI,9CI);2-Chloro-5-hydroxypyrimidine ISO 9001：2015 REACH;TIANFU-CHEM 2-Chloro-5-hydroxypyrimidine 4983-28-2
- CBNumber:
- CB0947875
- Summenformel:
- C4H3ClN2O
- Molgewicht:
- 130.53
- MOL-Datei:
- 4983-28-2.mol
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2-Chloro-5-hydroxypyrimidine Eigenschaften
- Schmelzpunkt:
- 195-196 °C
- Siedepunkt:
- 328.1±15.0 °C(Predicted)
- Dichte
- 1.513±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 6.17±0.23(Predicted)
- Aussehen
- Off-white to light brown Solid
- InChI
- InChI=1S/C4H3ClN2O/c5-4-6-1-3(8)2-7-4/h1-2,8H
- InChIKey
- BOGPIHXNWPTGNH-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC=C(O)C=N1
- CAS Datenbank
- 4983-28-2(CAS DataBase Reference)
2-Chloro-5-hydroxypyrimidine Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
2-Chloro-5-hydroxypyrimidine is an intermediate used to synthesize tandospirone derivatives with anxiolytic activities.
Synthese
2-Chloro-5-methoxypyrimidine (0.46 g, 3.18 mmol) in methylene chloride (10 mL) was treated with 1.0 N boron tribromide (16 mL, 16 mmol) at room temperature. The solution was stirred overnight. After that, the reaction was partitioned between saturated NaHCO3 and DCM. The aqueous layer was extracted with additional DCM. Combined the organic layers and dried (MgSO4), filtered, and concentrated to obtain the crude product. The residue was purified by flash column chromatography on silica gel to give 2-Chloro-5-hydroxypyrimidine.
2-Chloro-5-hydroxypyrimidine Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
2-Chloro-5-hydroxypyrimidine Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 295)Lieferanten
4983-28-2()Verwandte Suche:
- 2-Chloro-5-hydroxypyrimidine
- 5-Pyrimidinol, 2-chloro- (7CI,8CI,9CI)
- 2-Chloro-5-hydroxypyrimid...
- 5-PyriMidinol,2-chloro-
- 2-Chloropyrimidin-5-ol, 2-Chloro-5-hydroxy-1,3-diazine
- 2-Chloro-5-hydroxypyrimidine 98%
- 2-Chloro-5-pyrimidinol
- 2-Chloro-5-hydroxypyrimidine ISO 9001：2015 REACH
- Piribedil Impurity 17
- TIANFU-CHEM 2-Chloro-5-hydroxypyrimidine 4983-28-2
- 2-Chloropyrimidin-5-ol
- 4983-28-2
- 1983-28-2
- Heterocycle-Pyrimidine series
- PYRIMIDINE
- pharmacetical
- Pyrimidines
