Milbemycin oxime
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- CAS-Nr.
- 129496-10-2
- Englisch Name:
- Milbemycin oxime
- Synonyma:
- Milbemite;Milbexime;Mibemycin oxime;Milbemycin oxime;Milbemyein oxime;Milbemycin oxime CRS;β-phenylacrylophenone;Milbemycin oxime 92~95%;Milbemycin Oxime (200 mg);Milbemycin Oxime (1443806)
- CBNumber:
- CB11104418
- Summenformel:
- 2C32H45NO7.2C31H43NO7
- Molgewicht:
- 2194.78
- MOL-Datei:
- 129496-10-2.mol
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Milbemycin oxime Eigenschaften
- Schmelzpunkt:
- 169.6-177.4°
- Flammpunkt:
- 412℃
- storage temp.
- Store at -20°C
- L?slichkeit
- DMSO:100.0(Max Conc. mg/mL);91.13(Max Conc. mM)
- Aggregatzustand
- A crystalline solid
- Farbe
- White to off-white
- Stabilit?t:
- Hygroscopic
- Major Application
- pharmaceutical (small molecule)
- InChIKey
- LKMMLHTWKLEARD-MGZQXKBQSA-N
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| RIDADR |
2588 |
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| WGK Germany |
3 |
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| HazardClass |
6.1(b) |
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| PackingGroup |
III |
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| HS Code |
2932206000 |
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| Speicherklasse |
11 - Combustible Solids |
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| Hazard Classifications |
Aquatic Acute 1
Aquatic Chronic 1 |
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| Toxizit?t |
LD50 orally in mice: 1000-1500 mg/kg (Ciba-Geigy) |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H410 |
Sehr giftig für Wasserorganismen mit langfristiger Wirkung. |
Langfristig (chronisch) gew?ssergef?hrdend |
Kategorie 1 |
Warnung |
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P273, P391, P501 |
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| Sicherheit |
| P273 |
Freisetzung in die Umwelt vermeiden. |
| P391 |
Verschüttete Mengen aufnehmen. |
| P501 |
Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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Milbemycin oxime Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Milbemycin oxime is a semi-synthetic macrocyclic lactone prepared by the oxidation and oximation of a mixture of two natural products, milbemycin A3 and A4 (in ~30:70 ratio). Milbemycin oxime is used therapeutically for the prevention of intestinal parasites in dogs. Like the other milbemycin/avermectins, it was developed for intestinal parasite control in animals and acts by opening glutamate sensitive chloride channels in neurons of invertebrates leading to paralysis by hyperpolarisation of these cells and signal transfer blocking.
Clinical Use
Milbemycin oxime (Milbemycin) is available as an oral chewable tablet (2.3–27 mg) for heartworm prevention in dogs and cats, as well as a 0.1% otic solution for treating ear mites. It is not available in a more concentrated dosage form, so overdoses are relatively rare[1].
Veterinary Drugs and Treatments
Milbemycin tablets are labeled as a once-a-month heartworm
preventative (Dirofilaria immitis) and for hookworm control
(Ancylostoma caninum). It has activity against a variety of other
parasites, including adult hookworms (A. caninum), adult roundworms
(T. canis, T. leonina) and whipworms (Trichuris vulpis). In
cats, milbemycin has been used successfully to prevent larval infection
of Dirofilaria immitis.
Milbemycin, like ivermectin can be used for treatment of generalized
demodicosis in dogs, but treatment can be significantly more
expensive. It is likely safer to use in breeds susceptible to mdr1 genetic
mutation (Collies, Shelties, Australian shepherds, etc.) at the
doses used for this indication, but neuro toxicity is possible. Older
dogs, those that have had a long duration of disease prior to treatment,
and dogs with pododemodicosis appear have a lower success
rate with milbemycin treatment.
Milbemycin oxime Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Milbemycin oxime Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 340)Lieferanten
129496-10-2()Verwandte Suche:
- Milbemycin oxime
- Milbemycin Oxime (200 mg)
- Milbemycin oxime CRS
- Milbemycin Oxime (Mixture of Milbemycin Oxime A3 and A4)
- Milbemycin OximeQ: What is
Milbemycin Oxime Q: What is the CAS Number of
Milbemycin Oxime Q: What is the storage condition of
Milbemycin Oxime
- Milbemycin Oxime (1443806)
- β-phenylacrylophenone
- Milbemite
- Milbemycin, oxime (9CI, ACI)
- Mibemycin oxime
- Milbemycin Oxime (Mixture of Milbemycin Oxime A3 and Milbemycin Oxime A4, 20:80)
- Milbemyein oxime
- Milbexime
- Milbemycin oxime, 10 mM in DMSO
- Milbemycin oxime 92~95%
- 129496-10-2
- C63H88N2O14
- APIs for Veterinary
- Inhibitors
- API
- 129496-10-2
