Milrinon
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- CAS-Nr.
- 78415-72-2
- Bezeichnung:
- Milrinon
- Englisch Name:
- Milrinone
- Synonyma:
- Primacor;Milirinone;Milrinone USP;YM-018;Minong;Milrila;Corotrop;win47203;Mirinone;Corotrope
- CBNumber:
- CB8695411
- Summenformel:
- C12H9N3O
- Molgewicht:
- 211.22
- MOL-Datei:
- 78415-72-2.mol
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Milrinon Eigenschaften
- Schmelzpunkt:
- >3000C
- Siedepunkt:
- 350.9°C (rough estimate)
- Dichte
- 1.1922 (rough estimate)
- Brechungsindex
- 1.5700 (estimate)
- storage temp.
- 2-8°C
- L?slichkeit
- DMSO: >10 mg/mL
- Aggregatzustand
- powder
- pka
- 7.21±0.10(Predicted)
- Farbe
- off-white
- Wasserl?slichkeit
- Soluble in DMSO. Insoluble in water.
- Merck
- 14,6197
- Stabilit?t:
- Stable. Incompatible with strong oxidizing agents.
- InChI
- InChI=1S/C12H9N3O/c1-8-11(9-2-4-14-5-3-9)6-10(7-13)12(16)15-8/h2-6H,1H3,(H,15,16)
- InChIKey
- FYEJSUDMDUIMKJ-UHFFFAOYSA-N
- SMILES
- C1(C)NC(=O)C(C#N)=CC=1C1C=CN=CC=1
- CAS Datenbank
- 78415-72-2(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
T,T+ |
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| R-S?tze: |
23/24/25-26/27/28 |
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| S-S?tze: |
36/37/39-45-22 |
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| RIDADR |
UN 2811 6.1/PG 3 |
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| WGK Germany |
3 |
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| RTECS-Nr. |
DW1762000 |
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| HazardClass |
6.1(b) |
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| PackingGroup |
III |
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| HS Code |
29337900 |
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| Speicherklasse |
6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects |
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| Hazard Classifications |
Acute Tox. 3 Oral |
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| Bildanzeige (GHS) |
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| Alarmwort |
Achtung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H301 |
Giftig bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 3 |
Achtung |
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P264, P270, P301+P310, P321, P330,P405, P501 |
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| Sicherheit |
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Milrinon Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R23/24/25:Giftig beim Einatmen, Verschlucken und Berührung mit der Haut.
R26/27/28:Sehr giftig beim Einatmen, Verschlucken und Berührung mit der Haut.
S-S?tze Betriebsanweisung:
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn m?glich, dieses Etikett vorzeigen).
S22:Staub nicht einatmen.
Beschreibung
Milrinone, an inhibitor of phosphodiesterase selective for fraction III PDE, exerts a
positive inotropic effect on the heart as well as a peripheral vasodilatory effect. Milrinone
given intravenously produces significant improvements on cardiac output, pulmonary
capillary wedge pressure and vascular resistance without significant effects on the heart
rate.
Chemische Eigenschaften
Crystalline Solid
Verwenden
It is used (particularly intravenously, as the lactate) for the short-term management of severe heart failure. Milrinone inhibits the action of phosphodiesterase-3 preventing degradation of cAMP. The corresponding increase in cAMP levels leads to increased activation of protein kinase A. It is a selective phosphodiesterase inhibitor with vasodilating and positive inotropic activity.
Allgemeine Beschreibung
Milrinone, 1,6-dihydro-2-methyl-6-oxo-3,4＇-bipyridine-5-carbonitrile (Primacor), is another dipyridinephosphodiesterase F-III inhibitor that possesses pharmacologicalproperties similar to those of amrinone. The inhibitionof the degradation of cAMP results in an increase in the cardiacmuscle’s force of contraction.
Biologische Aktivit?t
Potent cAMP phosphodiesterase inhibitor (IC 50 = 56 nM for inhibition of PDE III). Has inotropic and vasodilator effects following oral or intravenous administration in vivo . Also available as part of the Phosphodiesterase Inhibitor Tocriset™ .
Milrinon Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Milrinon Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 554)Lieferanten
78415-72-2(Milrinon)Verwandte Suche:
- Corotrope
- Milrila
- 3-CYANO-6-METHYL-5-(4-PYRIDYL)-2-PYRIDONE
- 6-METHYL-5-(4-PYRIDYL)-2-PYRIDONE-3-CARBONITRILE
- 1,6-DIHYDRO-2-METHYL-6-OXO-(3,4'-BIPYRIDINE)-5-CARBONITRILE
- 6-Methyl-2-oxo-5-pyridin-4-yl-1H-pyridine-3-carbonitrile
- YM-018
- 2-Oxo-5-(4-pyridyl)-6-methyl-1,2-dihydropyridine-3-carbonitrile
- 3-Cyano-5-(4-pyridyl)-6-methyl-2(1H)-pyridone
- Milrinone,97%
- Milrinone,1,6-Dihydro-2-methyl-6-oxo-(3,4′-bipyridine)-5-carbonitrile
- Milrinone (500 mg)
- 6-Methyl-2-oxo-5-(pyridin-4-yl)piperidine-3-carbonitrile
- [3,4'-Bipyridine]-5-carbonitrile, 1,6-dihydro-2-Methyl-6-oxo-
- 2-Methyl-6-oxo-1,6-dihydro-[3,4']bipyridinyl-5-carbonitrile
- Milrinone(PriMacor)
- Milrinone API
- Corotrop
- 6-Methyl-5-(4-pyridyl)-2-pyridone-3-carbonitrile
3-Cyano-6-methyl-5-(4-pyridyl)-2-pyridone
- PriMacor IV
- 1,6-DIHYDRO-2-METHYL-6-OXO-3,4-BIPYRIDINE-5-CARBONITRILE
- 1,2-DIHYDRO-6-METHYL-2-OXO-5-(4-PYRIDINYL)-NICOTINONITRILE
- MILRINONE
- 4’-bipyridine)-5-carbonitrile,1,6-dihydro-2-methyl-6-oxo-(
- win47203
- MilrinoneUsDmf
- 2-METHYL-6-OXO-1,6-DIHYDRO-3,4'-BIPYRIDINE-5-CARBONITRILE(MILRINONE)
- 1,2-DIHYDRO-6-METHYL-2-OXO-5-(4-PYRIDINYL)- NICOTINONITRILES(MILRINONE)
- 6-Dihydro-2-methyl-6-oxo-(3,4'-bipyridine)-5-carbonitrile
- MILKTHISTLEP.E
- 1,2-Dihydro-6-methyl-2-oxo-5-pyridin-4-ylnicotinonitrile
- Milrinone,6-Dihydro-2-methyl-6-oxo-(3,4′-bipyridine)-5-carbonitrile
- Milrinone, >=99%
- Milrinone Injection
- Milrinone - CAS 78415-72-2 - Calbiochem
- Milrinone Milrinone
- Milrinone>
- 2-Methyl-6-oxo-1,6-dihydro-[3,4'-bipyridine]-5-carbonitrile
- Milrinone USP/EP/BP
- Milrinonee
- Milrinone (Win47203
- MilrinoneQ: What is
Milrinone Q: What is the CAS Number of
Milrinone Q: What is the storage condition of
Milrinone Q: What are the applications of
Milrinone
- Milrinone, ≥98%
- Milrinone (1443908)
- Primacor
- Mirinone
- O-(6-bromoethyl)hydroxylamine
- Milrinone USP
- Minong
- Millinone
- Milrinone, 10 mM in DMSO
- Milrinone - Bio-X ?
- Milirinone
- 78415-72-2
- 74815-72-2
- C12H9N3O
- Phosphodiesterase Inhibitors
- G Proteins and Cyclic Nucleotides
