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CDK1/2InhibitorIII

CDK1/2InhibitorIII Struktur
443798-55-8
CAS-Nr.
443798-55-8
Englisch Name:
CDK1/2InhibitorIII
Synonyma:
2 Inhibitor III;CDK1/2InhibitorIII;Cdk-1/2 Inhibitor III,Cdk1/2 Inhibitor III;5-amino-N-(2,6-difluorophenyl)-3-(4-sulfamoylanilino)-1,2,4-triazole-1-carbothioamide;1H-1,2,4-Triazole-1-carbothioamide, 3-amino-5-[[4-(aminosulfonyl)phenyl]amino]-N-(2,6-difluorophenyl)-
CBNumber:
CB11113964
Summenformel:
C15H13F2N7O2S2
Molgewicht:
425.44
MOL-Datei:
443798-55-8.mol

CDK1/2InhibitorIII Eigenschaften

Siedepunkt:
649.1±65.0 °C(Predicted)
Dichte
1.72±0.1 g/cm3(Predicted)
storage temp. 
+2C to +8C
L?slichkeit
DMSO: 10mg/mL
THF: soluble
acetone: soluble
Aggregatzustand
White solid
pka
6.61±0.70(Predicted)
Farbe
white
InChI
1S/C15H13F2N7O2S2/c16-10-2-1-3-11(17)12(10)21-15(27)24-13(18)22-14(23-24)20-8-4-6-9(7-5-8)28(19,25)26/h1-7H,(H,21,27)(H2,19,25,26)(H3,18,20,22,23)
InChIKey
ARIOBGGRZJITQX-UHFFFAOYSA-N
SMILES
Fc1c(c(ccc1)F)NC(=S)[n]2nc(nc2N)Nc3ccc(cc3)[S](=O)(=O)N

Sicherheit

WGK Germany  WGK 1
Speicherklasse 11 - Combustible Solids

CDK1/2InhibitorIII Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Cyclin-dependent kinases (Cdks) are key regulators of cell cycle progression and are therefore promising targets for cancer therapy. Cdk1/2 Inhibitor III is a cell-permeable inhibitor of Cdk1/cyclin B and Cdk2/cyclin A (IC50s = 0.6 and 0.5 nM, respectively). It less potently inhibits CDC2-like kinases 1 and 3, VEGFR2, and GSK-3β (IC50s = 8.9, 29, 32, and 140 nM, respectively) and is without effect against a panel of other kinases. Cdk1/2 Inhibitor III blocks the growth of several cancer cell lines (IC50 values range from 20 to 92 nM).

Allgemeine Beschreibung

A cell-permeable triazolo-diamine compound that displays anti-proliferative properties in various human cancer cells (IC50 = 20 nM, 35 nM and 92 nM in HCT-116, HeLa, and A375 cells, respectively). Acts as a highly potent, reversible, ATP-competitive inhibitor of Cdk1/cyclin B and Cdk2/cyclin A (IC50 = 600 pM and 500 pM, respectively) with selectivity over VEGF-R2 (IC50 = 32 nM), GSK-3β (IC50 = 140 nM), and a panel of eight other kinases (IC50 ≥ 1 μM).

Biochem/physiol Actions

Cell permeable: yes

CDK1/2InhibitorIII Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


CDK1/2InhibitorIII Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 25)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
TargetMol Chemicals Inc.
+1-781-999-5354; +17819995354
marketing@targetmol.com United States 32466 58
BOC Sciences
16314854226; +16314854226
inquiry@bocsci.com United States 19853 58
TargetMol Chemicals Inc.
+1-781-999-5354;
support@targetmol.com United States 39037 58
Aladdin Scientific

tp@aladdinsci.com United States 52923 58
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627
info@efebio.com China 9804 58
Energy Chemical 021-58432009 400-005-6266
marketing@energy-chemical.com China 44918 58
cjbscvictory 13348960310 13348960310
3003867561@qq.com China 10318 58
TargetMol Chemicals Inc. 4008200310 15002144251
marketing@tsbiochem.com China 24957 58
Nantong Hanfang Biotechnology Co. , Ltd. hanfangpharma@126.com; 18616537568
hanfangpharma@126.com China 25801 58
Sangon Biotech (Shanghai) Co.,Ltd. --
Sales@sangon.com China 6710 58

  • CDK1/2InhibitorIII
  • 5-amino-N-(2,6-difluorophenyl)-3-(4-sulfamoylanilino)-1,2,4-triazole-1-carbothioamide
  • 2 Inhibitor III
  • Cdk-1/2 Inhibitor III,Cdk1/2 Inhibitor III
  • 1H-1,2,4-Triazole-1-carbothioamide, 3-amino-5-[[4-(aminosulfonyl)phenyl]amino]-N-(2,6-difluorophenyl)-
  • 443798-55-8
  • C15H13F2N7O2S2
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