Cdk1/2阻害剤III 価格

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Cdk1/2阻害剤III 化學(xué)特性,用途語,生産方法

使用

Cyclin-dependent kinases (Cdks) are key regulators of cell cycle progression and are therefore promising targets for cancer therapy. Cdk1/2 Inhibitor III is a cell-permeable inhibitor of Cdk1/cyclin B and Cdk2/cyclin A (IC50s = 0.6 and 0.5 nM, respectively). It less potently inhibits CDC2-like kinases 1 and 3, VEGFR2, and GSK-3β (IC50s = 8.9, 29, 32, and 140 nM, respectively) and is without effect against a panel of other kinases. Cdk1/2 Inhibitor III blocks the growth of several cancer cell lines (IC50 values range from 20 to 92 nM).

一般的な説明

A cell-permeable triazolo-diamine compound that displays anti-proliferative properties in various human cancer cells (IC₅₀ = 20 nM, 35 nM and 92 nM in HCT-116, HeLa, and A375 cells, respectively). Acts as a highly potent, reversible, ATP-competitive inhibitor of Cdk1/cyclin B and Cdk2/cyclin A (IC₅₀ = 600 pM and 500 pM, respectively) with selectivity over VEGF-R2 (IC₅₀ = 32 nM), GSK-3β (IC₅₀ = 140 nM), and a panel of eight other kinases (IC₅₀ ≥ 1 μM).

Biochem/physiol Actions

Cell permeable: yes

Cdk1/2阻害剤III 上流と下流の製品情報(bào)

原材料

準(zhǔn)備製品

Cdk1/2阻害剤III 生産企業(yè)

名前	電話番號(hào)	電子メール	國(guó)籍	製品カタログ	優(yōu)位度
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32466	58
BOC Sciences	16314854226; +16314854226	inquiry@bocsci.com	United States	19853	58
TargetMol Chemicals Inc.	+1-781-999-5354;	support@targetmol.com	United States	39037	58
Aladdin Scientific		tp@aladdinsci.com	United States	52923	58
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9804	58
Energy Chemical	021-58432009 400-005-6266	marketing@energy-chemical.com	China	44918	58
cjbscvictory	13348960310 13348960310	3003867561@qq.com	China	10318	58
TargetMol Chemicals Inc.	4008200310 15002144251	marketing@tsbiochem.com	China	24957	58
Nantong Hanfang Biotechnology Co. , Ltd.	hanfangpharma@126.com; 18616537568	hanfangpharma@126.com	China	25801	58
Sangon Biotech (Shanghai) Co.,Ltd.	--	Sales@sangon.com	China	6710	58

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• 443798-55-8
• CDK1/2InhibitorIII
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• Cdk1/2阻害剤III
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