8-[(E)-2-(3,4-dimethoxyphenyl)ethenyl]-1,3-diethyl-7-methyl-purine-2,6 -dione
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- CAS-Nr.
- 155270-99-8
- Englisch Name:
- 8-[(E)-2-(3,4-dimethoxyphenyl)ethenyl]-1,3-diethyl-7-methyl-purine-2,6 -dione
- Synonyma:
- istradefylline;KW-6002;Itraphylline;Istradefylline-13C-d3;CS-285;Itofylline;stradefylline;Istradefylline 99%;10mg 50mg 100mg 1g 5g;KW6002/Istradefylline
- CBNumber:
- CB11261287
- Summenformel:
- C20H24N4O4
- Molgewicht:
- 384.43
- MOL-Datei:
- 155270-99-8.mol
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8-[(E)-2-(3,4-dimethoxyphenyl)ethenyl]-1,3-diethyl-7-methyl-purine-2,6 -dione Eigenschaften
- Schmelzpunkt:
- 191 °C
- Siedepunkt:
- 601.0±65.0 °C(Predicted)
- Dichte
- 1.24±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- L?slichkeit
- DMSO: soluble5mg/mL (clear solution)
- pka
- 0.47±0.70(Predicted)
- Aggregatzustand
- powder
- Farbe
- white to beige
- InChI
- InChI=1S/C20H24N4O4/c1-6-23-18-17(19(25)24(7-2)20(23)26)22(3)16(21-18)11-9-13-8-10-14(27-4)15(12-13)28-5/h8-12H,6-7H2,1-5H3/b11-9+
- InChIKey
- IQVRBWUUXZMOPW-PKNBQFBNSA-N
- SMILES
- N1(C)C2=C(N(CC)C(=O)N(CC)C2=O)N=C1/C=C/C1=CC=C(OC)C(OC)=C1
- CAS Datenbank
- 155270-99-8
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
T |
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| R-S?tze: |
25 |
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| S-S?tze: |
45 |
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| RIDADR |
UN 2811 6.1 / PGIII |
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| WGK Germany |
3 |
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| HS Code |
2933.99.7500 |
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| Speicherklasse |
6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects |
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| Hazard Classifications |
Acute Tox. 3 Oral |
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| Bildanzeige (GHS) |
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| Alarmwort |
Achtung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H301 |
Giftig bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 3 |
Achtung |
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P264, P270, P301+P310, P321, P330,P405, P501 |
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| Sicherheit |
| P301+P310 |
BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
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8-[(E)-2-(3,4-dimethoxyphenyl)ethenyl]-1,3-diethyl-7-methyl-purine-2,6 -dione Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
In March 2013, istradefylline (also known as KW-6002) was approved in Japan for adjunctive treatment of Parkinson’s disease (PD). Istradefylline acts by antagonism of the adenosine A
2A receptor, which is colocalized with dopamine D
2 receptors in the striatum, to enhance dopamine D
2-dependent signaling. Istradefylline is a light-sensitive compound and has been evaluated in vitro under low-light conditions to prevent isomerization of the (E)-styryl group and decomposition. Istradefylline has a Ki of 2.2 nM for the rat adenosine A
2A receptor and an ED
50 of 0.03 mg/kg, po, in reversal of haloperidol-induced catalepsy in mice. Further characterization showed istradefylline to have a Ki of 12 nM for the human adenosine A
2A receptor, to be highly selective, and to be a functional competitive antagonist. Istradefylline has activity alone and in combination with levo-dopa in preclinical animal models of PD. The synthesis of istradefylline was accomplished by 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide-mediated coupling of 5,6-diamino-1,3-diethyluracil with 3,4-dimethoxycinnamic acid, followed by cyclization upon treatment with aqueous NaOH, and selective methylation (MeI, K
2CO
3, and DMF).
Verwenden
Treatment of
Parkinson’s disease (adenosine A 2A receptor antagonist).
8-[(E)-2-(3,4-dimethoxyphenyl)ethenyl]-1,3-diethyl-7-methyl-purine-2,6 -dione Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
8-[(E)-2-(3,4-dimethoxyphenyl)ethenyl]-1,3-diethyl-7-methyl-purine-2,6 -dione Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 255)Lieferanten
155270-99-8()Verwandte Suche:
- 8-[(E)-2-(3,4-dimethoxyphenyl)ethenyl]-1,3-diethyl-7-methyl-purine-2,6 -dione
- 10mg 50mg 100mg 1g 5g
- (E)-8-(3,4-diMethoxystyryl)-1,3-diethyl-7-Methyl-1H-purine-2,6(3H,7H)-dione
- 8-[(E)-2-(3,4-diMethoxyphenyl)ethenyl]-1,3-diethyl-7-Methyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione
- Istradefylline (KW-6002)
- 1H-Purine-2,6-dione,8-[(1E)-2-(3,4-diMethoxyphenyl)ethenyl]-1,3-diethyl-3,7-dihydro-7-Methyl-
- Istradefylline
8-[(E)-2-(3,4-Dimethoxyphenyl)ethenyl]-1,3-diethyl-7-methylpurine-2,6-dione
- (E)-8-(3,4-Dimethoxystyryl)-1,3-diethyl-7-methylxanthine
- 8-[(1E)-2-(3,4-Dimethoxyphenyl)ethenyl]-1,3-diethyl-3,7-dihydro-7-methyl-1H-purine-2,6-dione
- (E)-8-(3,4-dimethoxystyryl)-1,3-diethyl-7-methyl-3,7-dihydro-1H-purin-2,6-dione
- CS-285
- 8-[(1E)-2-(2-(3,4-Dimethoxyphenyl)ethenyl]-1,3-diethyl-3,7-dihydro-7-methyl-1H-purine-2,6-dione
- 8-[(E)-2-(3,4-DIMETHOXYPHENYL)ETHENYL]-1,3-DI...
- 8-[(E)-2-(3,4-dimethoxyphenyl)ethenyl]-1,3-diethyl-7-methyl-purine-2,6 -dione USP/EP/BP
- Itraphylline impurities867
- stradefylline
- Itraphylline impurities5
- 2-dioleoyl-sn-glycero-3-phosphocholine
- KW6002/Istradefylline
- (E)-8-(3,4-Dimethoxystyryl)-1,3-diethyl-7-methyl-3,7-dihydro-1H-purine-2,6-dione
- Itofylline
- Istradefylline, 10 mM in DMSO
- Istradefyline - Bio-X ?
- Istradefylline 99%
- 8-[(E)-2-(3,4-Dimethoxyphenyl)ethenyl]-1,3-diethyl-7-methylpurine-2,6-dione - [AC77913]
- Istradefylline-13C-d3
- Itraphylline
- istradefylline
- KW-6002
- 155270-99-8
- Inhibitors
