1-ethyl-1H-pyrazol-4-amine
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- CAS-Nr.
- 876343-24-7
- Englisch Name:
- 1-ethyl-1H-pyrazol-4-amine
- Synonyma:
- 1-ethylpyrazol-4-amine;4-Amino-1-ethylpyrazole;1-ethyl-1H-pyrazol-4-amine;4-Amino-1-ethyl-1H-pyrazole;1H-Pyrazol-4-amine, 1-ethyl-;1-ethyl-1H-pyrazol-4-amine hydrochloride;1-ethyl-1H-pyrazol-4-amine(SALTDATA: HCl)
- CBNumber:
- CB11532949
- Summenformel:
- C5H9N3
- Molgewicht:
- 111.15
- MOL-Datei:
- 876343-24-7.mol
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1-ethyl-1H-pyrazol-4-amine Eigenschaften
- Siedepunkt:
- 238.6±13.0 °C(Predicted)
- Dichte
- 1.16±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 3.72±0.10(Predicted)
- Aussehen
- Purple to black Liquid
- CAS Datenbank
- 876343-24-7
1-ethyl-1H-pyrazol-4-amine Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
1-ethyl-1H-pyrazol-4-amine can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.
Synthese
General Procedure for the Synthesis of 4-Amino-l-N-alkylated-pyrazolesA solution of 4-nitropyrazole (300mg, 2.65mmol), potassium carbonate (2eq) and the alkylating reagent (l .leq) in acetonitrile (lOmL) was heated at 60C for 18h. After cooling to rt the mixture was diluted with EtOAc and washed with water. The organic phase was collected, dried (MgS04) and concentrated in vacuo. The crude residue was dissolved in methanol (lOmL), palladium on carbon (50mg) was added and the reaction was stirred under a balloon of hydrogen for 18h. The resulting mixture was filtered through Celite and the filtrate concentrated in vacuo to give the desired product. Procedure B:Example 11: 2-((6-( 1 -Ethyl- 1 H-pyrazo 1-4-ylamino)- 1 H-pyrazo lo [3 ,4-d]pyrimidin- 1 -yl) methyl)benzonitrileThe following compound was made according to the procedure in Example 1, using 1-ethyl- lH-pyrazo 1-4-amine. 1 -ethyl- lH-pyrazol-4-amine was prepared by Procedure A using ethyl iodide as alkylating agent: 1H NMR (d6-DMSO) | 9.94 (s, 1H), 8.94 (s, 1H), 8.10 (s, 2H), 7.91 (dd, 1H), 7.66 (td, 1H), 7.49-7.53 (m, 2H), 7.35-7.37 (m, 1H), 5.76 (s, 2H), 4.11 (q, 2H), 1.35 (t, 3H); LC-MS method B, (ES+) 345.1, RT = 8.58min.
1-ethyl-1H-pyrazol-4-amine Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
1-ethyl-1H-pyrazol-4-amine Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 73)Lieferanten
876343-24-7()Verwandte Suche:
- 1-ethyl-1H-pyrazol-4-amine
- 1-ethyl-1H-pyrazol-4-amine(SALTDATA: HCl)
- 1-ethyl-1H-pyrazol-4-amine hydrochloride
- 4-Amino-1-ethyl-1H-pyrazole
- 4-Amino-1-ethylpyrazole
- 1H-Pyrazol-4-amine, 1-ethyl-
- 1-ethylpyrazol-4-amine
- 876343-24-7
